Yongming Sang
Yongming (Simon) Sang
Associate Professor
Animal Genomics and Immunology
Department of Agricultural and Environmental Sciences
College of Agriculture, Human and Natural Sciences

Contact Information:
Office: 205B Lawson Hall
Lab: 202 Lawson Hall 

Telephone: 615-963-5183
FAX: 615-963-1557
E-mail: ysang@tnstate.edu

Research Interests:
My research efforts are directed at elucidating, molecularly and functionally, animal immune and metabolic genes, in particular those that have antimicrobial activities and therapeutic potential. We are using combined approaches of bioinformatics, genetics and molecular biology to elucidate genes or gene families that are potentially important in animal health. My current projects are focused on the following three directions: (1) Antimicrobial regulation against animal viral and bacterial diseases underlying immunometabolic function of immune molecules and cells; (2) Swine genome projects, animal comparative immunogenetics, and immunoreagent development; (3) Development of novel IFN-based antivirals and alternatives to antibiotics.

Selected Publications:
Schade A, Blecha F, Sang Y. (2017) Genome-wide profiling immunometabolic genes in Obese rats induced by high-fat diet synergized with infection of adenovirus serotype 36. (Abstract was published in Immunology 2014, AAI Annual Meeting, May 2-6, 2014, Pittsburgh, PA)

Miller LC, Sang Y, Bayles DO, Blecha F (2016). Comparative analysis of signature genes in Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)-infected porcine monocyte-derived dendritic cells at different activation statuses. J. Immunology 196 (1 Supplement), 216.19-216.19 (Paper is in review at Plos One, Co-corresponding author)

Sang Y, Liu Q, Lee J, Ma W, Blecha F. Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity. Sci Rep. 2016 Jun 30;6:29072. (Corresponding author).

Sang Y, Miller CL, Blecha F. Macrophage polarization in animal virus-host interaction. J Clin Cell Immunol, 2015 Apr;6(2). pii: 311. (Corresponding author)

Sang Y, Blecha F. Alternatives to antibiotics: an ecoimmunological view. Pathogens, 2014, 4(1):1-19. (Invited review, corresponding author).

Sang Y, Bergkamp J, Blecha F. Molecular Evolution of the Porcine Type I Interferon Family: Subtype-Specific Expression and Antiviral Activity. Plos One. 2014, 9(11):e112378. (Corresponding author).

Sang Y, Rowland RRR, Blecha F. Antiviral regulation underlying the activation status of porcine monocytic innate immune cells. J. Virol. 2014, 88(19):11395-410. (Corresponding author).

Sang Y, Brichalli W, Rowland RRR, Blecha F. Genome-wide analysis of antiviral signature genes in PRRSV-infected porcine macrophages at different activation statuses. Plos One 2014, 9(2):e87613. (Corresponding author).

Miller LC, Jiang Z, Sang Y, Harhay GP, Lager KM. Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheal-bronchial lymph nodes infected with influenza A virus. Vet Immunol Immunopathol. 2014, 159(3-4):180-91.  (Co-corresponding author).

Dawson HD, Loveland JE, Pascal G, Gilbert JGR, Uenishi H, Mann KM, Sang Y, et al. Structural and Functional Annotation of the Porcine Immunome. BMC Genomics. 2013, 14:332.

Groenen MA, Archibald AL, Uenishi H, Tuggle CK, Takeuchi Y, Rothschild MF, Rogel-Gaillard C, Park C, Milan D, Megens HJ, Li S, Larkin DM, Kim H, Frantz LA, Caccamo M, Ahn H, Aken BL, Anselmo A, Anthon C, Auvil L, Badaoui B, Beattie CW,
Bendixen C, Berman D, Blecha F, Blomberg J, Bolund L, Bosse M, Botti S, Bujie Z, Bystrom M, Capitanu B, Carvalho-Silva D, Chardon P, Chen C, Cheng R, Choi SH, Chow W, Clark RC, Clee C, Crooijmans RP, Dawson HD, Dehais P, De Sapio F, Dibbits B, Drou N, Du ZQ, Eversole K, Fadista J, Fairley S, Faraut T, Faulkner GJ, Fowler KE, Fredholm M, Fritz E, Gilbert JG, Giuffra E, Gorodkin J, Griffin DK, Harrow JL, Hayward A, Howe K, Hu ZL, Humphray SJ, Hunt T, Hornshøj H, Jeon JT, Jern P, Jones M, Jurka J, Kanamori H, Kapetanovic R, Kim J, Kim JH, Kim KW, Kim TH, Larson G, Lee K, Lee KT, Leggett R, Lewin HA, Li Y, Liu W, Loveland JE, Lu Y, Lunney JK, Ma J, Madsen O, Mann K, Matthews L, McLaren S, Morozumi T, Murtaugh MP, Narayan J, Nguyen DT, Ni P, Oh SJ, Onteru S, Panitz F, Park EW, Park HS, Pascal G, Paudel Y, Perez-Enciso M, Ramirez-Gonzalez R, Reecy JM, Rodriguez-Zas S, Rohrer GA, Rund L, Sang Y, et al. Analyses of pig genomes provide insight into porcine demography and evolution. Nature 2012, 491:393-398.

Sang Y, Shi J, Sang W, Rowland RRR, Blecha F. Replication competent recombinant PRRS viruses expressing indicator proteins and antiviral cytokines. Viruses, 2102, 4:102-116.

(See here for a full publication list.)

Teaching:
AG3340 – Anatomy & Physiology of Domestic Animals (undergraduate course) 
AG3430 – Animal Health and Diseases (undergraduate course) 
AG5160 – Animal Genetics and Breeding (graduate course) 

Education:
PhD, Immuno-physiology, Kansas State University, 2008
DSC, Plant Physiology and Biochemistry, Nanjing Agricultural University, 1996