Research Assistant Professor
Department of Family and Consumer Sciences
College of Agriculture, Human and Natural Sciences
Office Location: 204I Farrell-Westbrook
Identification and characterization of bioactive food compounds in the prevention of chronic diseases such as cardiovascular disease, obesity and diabetes, and prolong of healthy lifespan
Understanding the comprehensive and integrative relationship among nutrients, lifestyle and health
Development of preventive/therapeutic strategies and approaches to treat and prevent chronic diseases and strengthen health life.
Refereed journal Articles -22
International Conference Proceedings -13
Most Significant Publications:
1. Si Hongwei, Fu Z, Jia Z, Velayutham A, Liu D. 2011 Cocoa flavonoid epicatechin promotes health and lifespan in obese diabetic mice and Drosophila. Journal of Nutrition (in press).
2. Guri, AJ, Hontecillas R, Ferrer G, Casagran O, Liu D, Si Hongwei and Bassaganya-Riera J. 2010 Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4(+) T cell recruitment into the aortic wall. Journal of Nutritional Biochemistry 21(12):1178-85.
3. Si Hongwei. Liu D. 2009 Genistein protects against tumor necrosis factor-alpha-induced apoptosis of human endothelial cells through activation of p38 MAP kinase. Apoptosis. 14:66-76.
4. Si Hongwei. Liu D. 2008 Genistein, a soy phytoestrogen, up-regulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats. Journal of Nutrition. 138:297-304.
5. Guri, AJ, Hontecillas R, Ferrer G, Casagran O, Wankhade U, Noble A.M, Eizirik D, Ortis F, Cnop M, Liu D, Si Hongwei and Bassaganya-Riera J. 2008 The loss of PPAR γ in immune cells abrogates the ability of abscisic acid to improve insulin sensitivity through a mechanism involving suppression of MCP-1 expression and macrophage infiltration into white adipose tissue. Journal of Nutritional Biochemistry. 19(4):216-28.
6. Si Hongwei. Liu D. 2007 Phytochemical genistein in the regulation of vascular function: new insights. Current Medicinal Chemistry. 14 (24):2581-9
7. Liu D, Si Hongwei, Reynolds KA, Wei Z, Jia Z, Dillon JS. 2007 Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Gi-protein-dependent activation of phosphatidylinositol 3-Kinase/Akt and regulation of anti-apoptotic bcl-2 expression. Endocrinology 148(7):3068-3076
8. Guri AJ, Hontecillas R, Si Hongwei, Liu D, Bassaganya-Riera J. 2007 Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db/db mice fed high-fat diets. Clinical Nutrition. 26(1):107-16.
9. Liu D, Zhen W, Yang Z, Carter JD, Si Hongwei, Reynolds KA. 2006 Genistein acutely stimulates insulin secretion in pancreatic beta-cells through a cAMP-dependent protein kinase pathway. Diabetes. 55(4):1043-50
NUFS 4520-Clinical Nutrition
Recent Honors and Awards:
Hepler Fellowship, Virginia Polytechnic Institute and State University 2007
John Lee Pratt Fellowship, Virginia Polytechnic Institute and State University 2004 - 2007
Editorial Board of Journal of Cardiovascular Disease Research
Reviewer of Manuscripts/Grants Proposals
British Journal of Nutrition
Current Medicinal Chemistry
Journal of Agricultural and Food Chemistry
Molecular and Cellular Biochemistry
AHA Postdoctoral Fellowship
AHA Beginning Grant-In-Aid
Jeffress Memorial Trust
Journal of Cardiovascular Disease Research
D.V.M. –Gansu Agricultural University
M.Sc (Microbiology and Immunology - Gansu Agricultural University
Ph.D.( Human Nutrition) – Virginia Polytechnic Institute and State University
Date joined staff: 2010