Dr. Margaret Whalen
Contact Information:
MARGARET M. WHALEN, Ph. D.
Professor
Department of Chemistry
Tennessee State University, Nashville, TN 37209-1561
Telephone: (615) 963-5247 (office)
Fax: (615) 963-5326; email: mwhalen@tnstate.edu
Education:
B.S. in Chemistry. South Dakota School of Mines and Technology, Rapid City, SD
Ph. D. in Biochemistry. University of New Mexico School of Medicine, Albuquerque, NM
Post-doctoral Fellow. Neurobiology Group, Life Sciences Division, Los Alamos National Laboratory, Los Alamos, NM
Professional Experience:
Professor, Department of Chemistry, Tennessee State University, Nashville, TN
Associate Professor, Department of Chemistry, Tennessee State University, Nashville, TN
Assistant Professor, Department of Chemistry, Tennessee State University, Nashville, TN
Assistant Professor, Department of Chemistry, Murray State University, Murray, KY
Research Assistant Professor, Department of Medicine, Division of Rheumatology,University of
New Mexico School of Medicine, Albuquerque, NM
Staff Member, Neurobiology section, Physiology Group (LS-1), Life Sciences Division, Los Alamos National Laboratory, Los Alamos, NM
Recent publications in refereed journals:
1. Wilburn, W., Jamal, S., Ismail, F., Brooks, D., Whalen, M.M. 2021. Evaluation of Triclosan exposure on secretion of pro-inflammatory cytokines from human immune cells. Environ. Toxicol. Pharm. In press
2. Sushak, L., Gabure, S., Maise, J., Arnett, J., Whalen, M.M. 2020. Dibutyltin alters immune cell production of the pro-inflammatory cytokines interleukin (IL) 1β and IL-6: role of mitogen-activated protein kinases and changes in mRNA. J. Appl. Toxicol. 40:1047-1059.
3. Martin, T.J., Gabure, S., Maise, J., Snipes, S., Peete, M., Whalen, M.M. 2019. The Organochlorine Pesticides Pentachlorophenol and Dichlorodiphenyltrichloroethane Increase Secretion and Production of Interleukin 6 by Human Immune cells. Environ. Toxicol. Pharm. 72: 103263 11pages
4. Martin, T.J., Maise, J., Gabure, S., Whalen, M.M. 2019. Exposures to the Environmental Contaminants Pentachlorophenol and Dichlorodiphenyltrichloroethane Increase Production of the Pro-inflammatory cytokine, Interleukin 1-Βeta (IL-1β), in Human Immune Cells. J. Appl. Toxicol. 39:1132-1142.
5. Ignacio, R.M.C., Lee, E.S., Wilson, A.J., Beeghly-Fadiel, A., Whalen, M.M,
Son, D.S. 2018. Obesity-Induced Peritoneal Dissemination of Ovarian Cancer and Dominant
Recruitment of Macrophages in Ascites. Immune Netw. 18:e47.
6. Brown, S., Hamza, N., Boules, M., Wang, X., Whalen, M.M. 2018. Synthesis of interleukin 1 beta and interleukin 6 in human lymphocytes is stimulated by tributyltin. Archives of Toxicology 92:2573-2586.
7. Ignacio, R.M.C., Lee, E.S., Wilson, A.J., Beeghly-Fadiel, A., Whalen, M.M,
Son, D.S. 2018. Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant
Ovarian Cancer. Immune Netw. 18:e29
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8. Ignacio, R.M.C., Dong, Y.L., Kabir, S.M., Choi, H., Lee, E.S., Wilson, A.J., Beeghly-Fadiel, A., Whalen, M.M, Son, D.S. 2018. CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer. Oncotarget. 2018 Jan 15;9(11):9751-9765
9. Lawrence, S., Ismail, F., Jamal, S.Z., Whalen, M.M. 2018 Tributyltin (TBT) Stimulates Synthesis of Interferon gamma (IFNγ) and Tumor Necrosis Factor Alpha (TNFα) in Human Lymphocytes. J. Appl. Toxicol. 38:1081-1090. 10. Vercruysse, K., Clark, A., Alatas, N., Brooks, D., Hamza, N., Whalen, M. 2018. Polysaccharide-mediated synthesis of melanins from serotonin and other 5-hydroxy indoles. Future Science OA volume 4 p. FSO280.
11. Ignacio, R.M.C. Dong, Y-L., Kabir, S.M., Choi, H., Lee, E-S., Beeghly-Fadiel, A., Whalen, M.M., Son, D-S. 2018. CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer. Oncotarget 9:9751-9765 PMCID: PMC5839399
12. Yasmin, S., Whalen, M.M. 2018. Flame Retardants, Hexabromocyclododecane (HBCD) and Tetrabromobisphenol A (TBBPA) Alter Secretion of Tumor Necrosis Factor Alpha (TNFα) from Human Immune Cells. Archives of Toxicology 92:1483-1494 PMCID: PMC5884737
13. Brown, S., Wilburn, W., Martin, T., Whalen, M.M. 2018. Butyltin compounds alter secretion of interleukin 6 from human immune cells. J. Appl. Toxicol. 38: 201-218.
14. Massawe, R., Drabo, L., Whalen, M.M. 2017. Effects of Pentachlorophenol and Dichlorodiphenyltrichloroethane on Secretion of Interferon gamma (IFNγ) and Tumor Necrosis Factor alpha (TNFα) from Human Immune Cells. Toxicol. Mech. Methods 27: 223-235 PMCID:PMC5453502
15. Martin, T.J., Whalen, M.M. 2017.Exposures to the Environmental Toxicants Pentachlorophenol (PCP) and Dichlorodiphenyltrichloroethane (DDT) Modify Secretion of Interleukin 1-Βeta (IL-1β) from Human Immune Cells. Archives of Toxicology 91: 1795-1808 PMCID: PMC5336548 16. Brown, S., Tehrani, S., Whalen M.M. 2017. Dibutyltin-Induced Alterations of Interleukin 1 Beta Secretion From Human Immune Cells. J. Appl. Toxicology 37:181-191 PMCID:PMC5114172 17. Lawrence, S., Pellom, Jr., S.T., Shanker, A., Whalen, M.M. 2016. Tributyltin Exposure Alters Cytokine Levels in Mouse Serum. J. Immunotox. 13:870-878 PMCID:PMC5159249 18. Amara S,1 Whalen M,2 Tiriveedhi V 3 2016 High salt induces anti-inflammatory MΦ2-like phenotype in peripheral macrophages. Biochemistry and Biophysics Reports 7: 1-9. PMCID:PMC4877052
19. Anisuzzaman, S,. Whalen, M.M. 2016. Tetrabromobisphenol A and Hexabromocyclododecane Alter Secretion of IL-1β from Human Immune Cells. J. Immunotox. 13:403-416 PMCID: PMC4910520
20. Almughamsi, H., Whalen, M.M. 2016. Hexabromocyclododecane and Tetrabromobisphenol A alter secretion of interferon gamma (IFNγ) from human immune cells. Archives of Toxicology 90:1695-1707 PMCID: PMC4767696
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