Dr. Ho-Jin Koh

Associate Professor

 

Department of Biological Sciences
College of Life & Physical Sciences
Office: 312 Harned Hall
Phone: 615-963-5784
Email: hkoh@tnstate.edu

Education

1995  B.S.       Kyungpook National University (Department of Genetic Engineering)
1997  M.S.      Kyungpook National University (Molecular Biology)
2002  Ph.D.    Kyungpook National University (Molecular Biology)

Research Interest(s): Skeletal muscular physiology

Publications

  1. Lee SM, Koh HJ, Huh TL, Park JW.   Radiation sensitivity of an Escherichia coli mutant lacking NADP+-dependent isocitrate dehydrogenase. Biochem. Biophys. Res. Commun. 1999;254:647-650
  2. Kim YO, Park SH, Kang YJ, Koh HJ, Kim SH, Park SY, Sohn U, Huh TL.   Assignment of mitochondrial NAD+-specific isocitrate dehydrogenase b subunit gene (IDH3B) to human chromosome band 20p13 by in situ hybridization and radiation hybrid mapping. Cytogenet. Cell Genet. 1999;86:240-241
  3. Kim YO, Koh HJ,Kim SH, Son BG, Huh JW, Jeong KS, Lee IJ, Song BJ, Huh TL.   Identification and functional characterization of novel and tissue-specific mitochondrial NAD+-dependent isocitrate dehydrogenase b subunit isoform. J. Biol. Chem. 1999;274:36866-36875
  4. Jo SH, Son MK, Koh HJ, Lee SM, Song IH, Kim YO, Jeong KS, Kim WB, Park JW, Song BJ, Huh TL. Control of mitochondrial redox balance and cellular defense against oxidative damage by the mitochondrial NADP+-dependent isocitrate dehydrogenase (IDPm). J. Biol. Chem. 2001;276:16168-16176
  5. Jo SH, Lee SH, Chun HS, Lee SM, Koh HJ, Lee SE, Chun JS, Park JW, Huh TL.   Cellular defense against UVB-induced phototoxicity by cytosolic NADP+-dependent isocitrate dehydrogenase. Biochem. Biophys.Res. Commun. 2002;292:542-549
  6. Lee SM*, Koh HJ*, Park DC, Song BJ, Huh TL, Park JW.   Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. Free Radic. Biol. Med. 2002;32:1185-1196 (* equal contribution)
  7. Lee SH, Jo SH, Lee SM, Koh HJ, Song H, Park JW, Lee WH, Huh TL.  Role of NADP+-dependent isocitrate dehydrogenase (NADP+-ICDH) on cellular defence against oxidative injury by gamma-rays. Int. J. Radiat. Biol. 2004;80:635-642
  8. Koh HJ, Lee SM, Do, KM, Son BC, Ryoo ZY, Chang KT, Chun JS, Park JW, Jeong KS, Choi MS, Son M, Park DC, Song BJ, Veech RL, Song H, Huh TL.  Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism. J. Biol. Chem. 2004;279:39968-39974
  9. Koh HJ, Arnolds DE, Fujii N, Rogers, MJ, Jessen N, Ho RC, Hirshman MF, Goodyear LJ.  Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol. Cell. Biol. 2006;26:8217-8227
  10. Koh HJ, Hirshman MF, He H, Li Y, Manabe Y, Balschi JA, Goodyear LJ.  Epinephrine is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes.  Biochem. J. 2007; 403:473-481
  11. Koh HJ , Brandauer JB, Goodyear LJ.AMPK and LKB1 and the Regulation of skeletal muscle metabolism.  Current Opinion in Clinical Nutrition and Metabolic Care. 2008; 11(3):227-232
  12. Treebak JT, Taylor EB, Witczak CA, An D, Toyoda T, Koh HJ, Xie J, Feeneer EP, Wojtaszewski JFP, Hirshman MF, and Goodyear LJ.  Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.  Am. J. Physiol. Endocrinol. Metab.  2010; 298(2): C377-385.
  13. Lee SH, Ha SO, Koh HJ, Kim K, Jeon SM, Choi MS, Kwon OS, and Huh TL.  Upregulation of Cytosolic NADP+-Dependent Isocitrate Dehydrogenase by Hyperglycemia Protects Renal Cells Against Oxidative Stress.  Mol. Cells 2010; 29: 203-208.
  14. Jessen N, Koh HJ, Folmes CD, Wagg C, Fujii N, Lofgren B, Wolf CM, Berul CI, Hirshman MF, Lopaschuk GD, and Goodyear LJ. Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function. Biochimica. et. Biophysica acta.- Molecular Basis of Disease 2010; 1802(7-8): 593-600.
  15. Koh HJ, Toyoda T, Fujii N, Jung MM, Rathod A, Middelbeek RJ, Lessard SJ, Treebak JT, Tsuchihara K, Esumi H, Richter EA, Wojtaszewski JFP, Hirshman MF, and Goodyear LJ.  The AMPK-related protein kinase SNARK mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proc. Natl. Acad. Sci.2010; 107(35): 15541-15546.
  16. Toyoda T, An D, Witczak CA, Koh HJ, Hirshman MF, Fujii N, and Goodyear LJ. Myo1c regulates glucose uptake in mouse skeletal muscle. J. Biol. Chem. 2011; 286(6): 4133-4140.
  17. Liew CW*, Boucher J*, Cheong JK*, Vernochet C, Koh HJ, Kawamori D, Hu J, Goodyear LJ, Farmer SR, Doria A, Bluher M, Hsu SI, and Kulkarni RN. Ablation of TRIP-Br2, a novel regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nature Medicine 2013; 19:217-226 (* equal contribution).
  18. Koh HJ*, Toyoda T, Didesch MM, Lee MY, Sleeman MW, Kulkarni RN, Musi N, Hirshman MF, and Goodyear LJ. Tribbles 3 Mediates ER Stress-Induced Insulin Resistance in Skeletal Muscle. Nat. Commun. 2013; 4:1871. 1038/ncomms2851 (* corresponding author).
  19. Lauritzen HP, Brandauer J, Schjerling P, Koh HJ, Treebak JT, Hirshman MF, Galbo H, and Goodyear LJ.  Contraction and AICAR Stimulate IL-6 Vesicle Depletion from Skeletal Muscle Fibers In Vivo.  Diabetes 2013; 62(9):3081-3092.
  20. An D, Lessard SJ, Toyoda T, Lee MY, Koh HJ, Qi L, Hirshman MF, and Goodyear LJ.  Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice.  Am. J. Physiol. Regul. Integr. Comp. Physiol. 2014; 306(12):R925-R933.
  21. Lessard SJ, Rivas DA, So K, Koh HJ, Queiroz AL, Hirshman MF, Fielding RA, and Goodyear LJ.  The AMPK-related kinase SNARK regulates muscle mass and myocyte survival.  J. Clin. Invest. 2015; Doi:10.1172/JCI79197.
  22. Jeong HW, Choi R, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, and Koh HJ.  Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling. Biochem. Biophys. Res. Commun. 2016;Doi:10.1016/j.bbrc.2016.01.064
  23. Koh HJ.  Regulation of exercise-stimulated glucose uptake in skeletal muscle.  Annals of Pediatric Endocrinology & Metabolism 2016;21(2):61-5
  24. Gao S, Durstine LJ, Koh HJ, Carver W, Frizzell N, and Carson JA.  Acute myotube protein synthesis regulation by IL-6 related cytokines. Am. J. Physiol. Cell. Physiol. 2017;Doi:10.1152/ajpcell.00112.2017
  25. Choi R, McConnahay A, Jeong HW, McClellan JL, Hardee JP, Carson JA, Hirshman MF, Goodyear LJ, and Koh HJ.  TRB3 regulates protein turnover in mouse skeletal muscle. Biochem. Biophys. Res. Commun. 2017;Doi:10.1016/j.bbrc.2017.09.134
  26. Hardee JP, Counts BR, Gao S, VanderVeen BN, Fix DK, Koh HJ, and Carson JA.  Inflammatory signaling regulates eccentric contraction-induced protein synthesis in cachectic skeletal muscle. J. Cachexia Sarcopenia Muscle 2017,Doi:10.1002/jcsm.12271
  27. Hardee JP, Fix DK, Wang X, Goldsmith EC, Koh HJ, and Carson JA.  Systemic IL-6 regulation of eccentric contraction-induced muscle protein synthesis. Am. J. Physiol. Cell. Physiol. 2018;Doi:10.1152/ajpcell.0063
  28. Sun XL, Lessard SJ, An D, Koh HJ, Esumi H, Hirshman MF, and Goodyear LJ.  Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart.  J. Cell. Biochem. 2018,Doi:10.1002/jcb.27425
  29. VanderVeen BN, Fix DK, Montalvo R, Counts BR, Murphy EA, Koh HJ, and Carson JA.  The regulation of skeletal muscle fatigability and mitochondrial function by chronically elevated IL-6.  Exp. Physiol. 2018,Doi:10.1113/EP087429
  30. Choi RH, McConahay A, Silvestre JG, Moriscot AS, Carson JA, and Koh HJ.  TRB3 regulates skeletal muscle mass in food deprivation-induced atrophy. The FASEB J. 2019;Doi:10.1096/fj.201802145RR
  31. Choi RH, McConahay A, Johnson M, Jeong HW, and Koh HJ.  Adipose tissue-specific knockout of AMPKα1/α2 results in normal AICAR tolerance and glucose metabolism. Biochem. Biophys. Res. Commun. 2019; Doi:10.1016/j.bbrc.2019.09.049
  32. Hardee JP, Fix DK, Koh HJ, Wang X, Goldsmith EC, and Carson JA.  Repeated eccentric contractions positively regulate muscle oxidative metabolism and protein synthesis during cancer cachexia in mice. J Appl Physiol 2020;Doi:10.1152/japplphysiol.00908.2019
  33. Choi RH, McConahay A, Johnson M, and Koh HJ.  Tribbles 3 expression in mouse skeletal muscle blunts exercise-induced skeletal muscle adaptation. In Revision
  34. Fix DK, Counts BR, Smuder AJ, Sarzynski MA Koh HJ, and Carson JA.  The effect of wheel running on fasting induced muscle AMPK signaling in tumor bearing mice. Submitted

Courses taught at TSU

Human Anatomy & Physiology, BIOL2210