Dr. Margaret Whalen

Margaret with student

 

Contact Information:

MARGARET M. WHALEN, Ph. D.

Professor

Department of Chemistry

Tennessee State University, Nashville, TN 37209-1561

Telephone: (615) 963-5247 (office)

Fax: (615) 963-5326; email: mwhalen@tnstate.edu

Education:

B.S. in Chemistry. South Dakota School of Mines and Technology, Rapid City, SD

Ph. D. in Biochemistry. University of New Mexico School of Medicine, Albuquerque, NM

Post-doctoral Fellow. Neurobiology Group, Life Sciences Division, Los Alamos National Laboratory, Los Alamos, NM

Professional Experience:

Professor, Department of Chemistry, Tennessee State University, Nashville, TN

Associate Professor, Department of Chemistry, Tennessee State University, Nashville, TN

Assistant Professor, Department of Chemistry, Tennessee State University, Nashville, TN

Assistant Professor, Department of Chemistry, Murray State University, Murray, KY

Research Assistant Professor, Department of Medicine, Division of Rheumatology,University of

New Mexico School of Medicine, Albuquerque, NM

Staff Member, Neurobiology section, Physiology Group (LS-1), Life Sciences Division, Los

Alamos National Laboratory, Los Alamos, NM

 

Recent publications in refereed journals:

Brown, S, Whalen, MM. 2015. Tributyltin alters secretion of interleukin 1 beta from human immune cells. Journal of Applied Toxicology in press

Cato, A, Celada. L, Kibakaya, EC, Simmons, N, Whalen, MM. 2014. Brominated Flame Retardants, Tetrabromobisphenol A and Hexabromocyclododecane activate mitogen-activated protein kinases (MAPKs) in human naturual killer cells.  Cell Biology and Toxicology 30:345-60

Amara, S., Lopez, K., Brown, S-K,  Whalen, M.,  Myles, E.L., Ivy, M.T., Johnson, T.,  Schey, K.L.  Richmond, A. Tiriveedhi, V. 2015.  Synergistic effect of pro-inflammatory TNF<alpha> and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis.  Molecular Immunology 64: 26-35.

Lawrence, S, Reid, J*, Whalen, MM. 2014.Secretion of interferon gamma (IFNγ) from human immune cells is altered by exposure to tributyltin (TBT) and dibutyltin (DBT). Environmental Toxicology in press

Celada, L.J., Whalen, M.M. 2014. Effects of Butyltins (BTs) on Mitogen-Activated-Protein Kinase Kinase Kinase (MAP3K) and Ras Activity in Human Natural Killer Cells. Journal of Appl. Toxicol. 34:1002-11

Hurt, K., Hurd-Brown, T., Whalen, M.M. 2013. Tributyltin and dibutyltin alter secretion of tumor necrosis factor alpha from human natural killer (NK) cells and a mixture of T cells and NK cells. Journal of Appl. Toxicol. 33:503-510 PMCID: PMC3570729

Hurd-Brown, T. Udoji, F., Martin, T., Whalen, M.M.2013. Effects of DDT and Triclosan on Tumor-cell Binding Capacity and Cell-Surface Protein Expression of Human Natural Killer Cells. Journal of Appl. Toxicol. 33:495-502 PMCID: PMC3459142

Hurd,T., Walker, J., Whalen, M.M. 2012. Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. Journal of Appl. Toxicol., 32: 627-634PMCID: PMC3428751

Hurd, T., Whalen, M.M. 2011. Tetrabromobisphenol A decreases cell-surface proteins involved in in human natural killer (NK) cell-dependent target cell lysis. Journal of Immunotoxicology 8: 219-227 PMCID: PMC3145820

Taylor, T.R., Whalen, M.M. 2011. Ziram Activates Mitogen-Activated Protein (MAP) Kinases and Decreases Cytolytic Protein Levels in Human Natural Killer Cells.  Toxicology Mechanisms and Methods  21:577-584 PMCID: PMC3183386

Dudimah. F.D., Abraha, A., Wang, X., Whalen, M.M. 2010. Activation of p44/42 in human natural killer cells decreases cell-surface protein expression: Relationship to tributyltin-induced alterations of protein expression. Toxicology Mechanisms and Methods 20:544-555 PMCID: PMC2962685

Abraha, A., Rana, K., Whalen, M.M. 2010. Role of protein kinase C in the TBT-induced inhibition of lytic function and MAPK activation in human natural killer cells. Arch. Environ. Cont. Toxicol. 59:661-669 PMCID: PMC2909453

Person, RJ, Whalen, MM. 2010. Effects of butyltin exposures on MAP kinase dependent transcription regulators in human natural killer cells. Toxicol. Mech. and Meth. 20:227-233 PMCID: PMC2874114

Odman-Ghazi, SO, Abraha, A, Isom, ET, Whalen, MM. 2010. Dibutyltin activates MAP kinases in human natural killer cells, in vitro. Cell Biology and Toxicology, 26:469-479. PMCID: PMC2892640

Udoji, F, Martin, T, Etherton, R, Whalen, MM. 2010. Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells, in vitro. J. Immunotoxicology. 7:205-212 PMCID: PMC2890036

Hinkson, NC, Whalen, MM. 2010. Hexabromocyclododecane Decreases Tumor-cell-binding Capacity and Cell-Surface Protein Expression of Human Natural Killer Cells. J. Appl. Toxicol. 30:302-309 PMCID: PMC2876233

Dudimah, FD, Griffey, D, Wang, X, Whalen, MM. 2010 Activation of p44/42 MAPK plays a role in the TBT-induced loss of human natural killer (NK) cell function. Cell Biology and Toxicology 26:435-444 PMCID: PMC2891216

Kibakaya, EC, Stephen, K, Whalen, MM. 2009. Tetrabromobisphenol A has immunosuppressive effects on human natural killer cells. J. Immunotoxicology 6: 285-292 PMCID: PMC2782892

Hinkson, NC, Whalen, MM. 2009. Hexabromocyclododecane decreases the lytic function and ATP levels of human natural killer cells. J. Appl. Toxicol. 29:656-661 PMCID: PMC2788026

Lane, R, Ghazi, SO, Whalen, MM. 2009. Increases in cytosolic calcium ion levels in human natural killer cells in response to butyltin exposure. Arch. Environ. Contam. Toxicol. 57: 816-825 PMCID: PMC2765521

Abraha, A. Whalen, MM. (2009) The role of p44/42 activation in tributyltin-induced inhibition of human natural killer cells: effects of MEK inhibitors. J. Appl. Toxicol. 29:165-173 PMCID:PMC2642538

Powell, JJ, Davis, MV, Whalen, MM. (2009) Glutathione diminishes tributyltin- and dibutyltin-induced loss of lytic function in human natural killer cells. Drug and Chemical Toxicology 32: 9-16 PMCID:PMC2704261

Taylor, TR, Whalen, MM. (2009) Effects of Ziram on tumor-cell-binding capacity, cell-surface marker expression and ATP levels of human natural killer cells. Cell Biology and Toxicology 25: 447-455 PMCID: PMC2732751

Nnodu, U, Whalen, MM. (2008) Pentachlorophenol decreases ATP levels in human natural killer cells. J. Appl. Toxicol. 28:1016-1020 PMCID:PMC2583398

Whalen, MM, DeWitt, JC, Luebke, RW. (2008) Serum supplementation modulates the effects of dibutyltin on human natural killer cell function. Toxicological Science 104: 312-319. PMCID: PMC2245884

Odman-Ghazi, SO, Person, RJ, Whalen, MM. (2008) Effects of tributyltin on protein tyrosine kinases and phospholipase C gamma in human natural killer cells. Toxicol. Mech. Meth., 18:25-33.

Holloway, LN, Pannell, KH, Whalen, MM. (2008) Effect of a series of triorganotins on ATP levels in human natural killer cells. Environ. Toxicol. Pharmacol., 25: 43-50.

Dudimah, FD, Gibson, C, Whalen, MM. (2007) Effect of Dibutyltin (DBT) on ATP levels in human natural killer cells. Environ. Toxicol., 22:117-123

Aluoch, AO, Odman-Ghazi, SO, Whalen, MM. (2007) Pattern of MAP kinases p44/42 and JNK activation by non-lethal doses of tributyltin in human natural killer cells. Arch. Toxicol., 81:271-277.

Dudimah, FD, Odman-Ghazi, SO, Hatcher, F, Whalen, MM. (2007) Effect of Tributyltin (TBT) on the ATP levels in human natural killer cells: Relationship to TBT- induced decreases in NK function. J. Appl. Toxicol., 27:86-94.

Gomez, FD, Apodaca, P, Holloway, LN, Pannell, KH, Whalen, MM. (2007) Effect of a series of triorganotins on the immune function of human natural killer cells. Environ. Toxicol. Pharmacol., 23:18-24

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