Dr. Venkataswarup Tiriveedhi
Associate Professor
Department of Biological Sciences
College of Life & Physical Sciences
Contact Information:
Office Location: 112-F McCord Hall
Office Telephone: 615-963-5758
Fax: 615-963-5747
Email: vtirivee@tnstate.edu
Education:
MBA, Business - Tennessee State University
MD, Medicine – Osmania Medical College, India
Ph.D., Biochemistry-The University of Southern Mississippi
PostDoc, Molecular Biology – Johns Hopkins University
PostDoc, Immunogenetics-Washington University School of Medicine
Research Interests: Role of cytokines in the development of inflammatory injury mediated carcinogenesis
Select Publications:
Allu AS and Tiriveedhi V (2021). Cancer Salt Nostalgia. Cells , 10(6): 1285.
Tiriveedhi V$, Ivy M, Myles EL, Zent R, Rathmell JC, Titze J (2021). Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response. Cancers (Basel) , 13(7): 1690. $Corresponding author.
Khandekar D, Tiriveedhi V. (2020) Role of BET inhibitors in Triple Negative Breast Cancer. Cancers (Basel) , 12(4): 784.
Raman D, Tiwari AK, Tiriveedhi V, Rhoades-Sterling JA (2020). Editorial: The Role of Breast Cancer Stem Cells in Clinical Outcomes. Frontiers in Oncology ; 10: 299.
Robinson K, Tiriveedhi V. (2020) Perplexing Role of P-Glycoprotein in Tumor Microenvironment. Frontiers in Oncology ; 10: 265.
Babaer D, Zheng M, Ivy MT, Tiriveedhi V (2019) Methylselenol producing selenocompounds enhance the efficiency of mammaglobin‑A peptide vaccination against breast cancer cells. Oncology Letters 18(6): 6891-1698.
Khandekar D, Amara S, Tiriveedhi V (2019) Immunogenicity of Tumor Initiating Stem Cells: Potential Applications in Novel Anticancer Therapy. Frontiers in Oncology 2019, 9: 315 (1-10).
Babaer D, Amara S, McAdory BS, Johnson O, Myles EL, Zent, R, Rathmell JC, Tiriveedhi V (2019) Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells. Cancers (Basel) 2019, 11(5): E672 (1-21).
V Tiriveedhi (2018) Impact of Precision Medicine on Drug Repositioning and Pricing: A Too Small to Thrive Crisis. Journal of Personalized Medicine 8(4):36 (1-11).
Albaqami J, Myles E L, Tiriveedhi V , Boadi W, Driggins N. (2018) The Effect of Onosma bracteatum in cancer cells. MOJ Bioequivalence & Bioavailability 5(6):321 ‒ 325.
V Tiriveedhi (2018) Vaccines: DNA. In: eLS. John Wiley & Sons, Ltd: Chichester. [Book Chapter]
Husaini B, Tiriveedhi V, Miller O, Novotny M, Zoorob R, Levine R. (2018) Examining effects of depression on hospital cost of breast cancer among women. EC Neurology 10.6.
Babaer D, Amara S, Ivy M, Zhao Y, Lammers PE, Titze JM, Tiriveedhi V (2018) High salt induces P-glycoprotein mediated treatment resistance in breast cancer cells through store operated calcium influx. Oncotarget 9 (38): 25193-25205.
Alatoibi D, Amara S, Johnson TL, Tiriveedhi V (2018) Potential anticancer effect of prostratin through SIK3 inhibition. Oncology Letters 15 (3): 3252- 3258.
Amara S, Majors C, Roy B, Hill S, Rose K, Myles, EL, Tiriveedhi V (2017) Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation. PLoS One 12 (6):e0180097.
Amara S, Tiriveedhi V (2017) Inflammatory role of high salt in tumor microenvironment. International Journal of Oncology 50:1477-1481.
Amara S, Tiriveedhi V (2017) The five immune forces impacting DNA-based cancer immunotherapeutic strategy. International Journal of Molecular Sciences 18: 650.
Amara S, Whalen M, Tiriveedhi V (2016) High salt induces anti-inflammatory MΦ2-like phenotype in peripheral macrophages. Biochemistry and Biophysics Reports 7: 1-9.
Amara S, Zheng M, Tiriveedhi V (2016) Oleanolic acid inhibits high salt induced exaggeration of Warburg-like metabolism in breast cancer cells. Cell Biochemistry and Biophysics 74 (3): 427-434.
Amara S, Alotaibi D, Tiriveedhi V (2016) NFAT-5/STAT-3 interaction mediates synergism of high salt with IL-17 towards induction of VEGF-A expression in breast cancer cells. Oncology Letter 12(2):933-943.
Amara S, Ivy MT, Myles E, Tiriveedhi V (2016) Sodium channel γENaC mediates IL-17 synergized high salt induced inflammatory stress in breast cancer cells. Cellular Immunology 302: 1-10.
Amara S, Lopez K, Banan B, Brown S-K, Whalen M, Myles E, Ivy MT, Johnson T, Schey KL, Tiriveedhi V (2015) Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis. Molecular Immunology 64 (1): 26-35
Platt D, Amara S, Mehta T, Vercuyssee K, Myles EL, Johnson T, Tiriveedhi V (2014) Violacein inhibits matrix metalloproteinase mediated CXCR4 expression: Potential anti-tumor effect in cancer invasion and metastasis. Biochemical Biophysical Research Communications 455 (1-2): 107-112.
Tiriveedhi V, Tucker N, Herndon J, Li L, Sturmoski M, Ellis MJ, Ma CX, Naughton M, Lockhart AC, Gao F, Fleming TP, Goedegebuure PS, Mohanakumar T, Gillanders WE. (2014) Safety and preliminary evidence of biological efficacy of a mammaglobin-A DNA vaccine in patients with stable metastatic breast cancer. Clinical Cancer Research 20 (23): 5964-5975. (Press Report on this article in TIME magazine http://time.com/3611635/breast-cancer-vaccine-safety-trial/)
Soysal SD, Muenst S, Kan-Mitchell J, Huarte E, Zhang X, Wilkinson-Ryan I, Flemin T, Tiriveedi V, Moanakumar T, Li L, erndon J, Oertli D, Goedegebuure SP, Gillanders WE. (2014) Identification and translational validation of novel mammaglobin-A CD8 T cell epitopes. Breast Cancer Research and Treatment 147 (3): 527-537.
Tiriveedhi V$ , Upadhya GA, Busch RA, Gunter KL, Dines JN, Knolhoff BL, Jia J, Sarma NJ, Ramachandran S, Anderson CD, Mohanakumar T, Chapman WC. (2014) Protective role of bortezomib in steatotic liver ischemia/reperfusion injury through abrogation of MMP activation and YKL-40 expression. Transplant Immunol ogy 30 (2-3):93-98. $Corresponding author.
Tiriveedhi V, Banan B, Deepti S, Nataraju A, Hachem R, Trulock E, Patterson AG, Mohanakumar T. (2014) Role of defensins in chronic lung allograft rejection. Human Immunology 75(4): 370-377.
Baskaran G, Tiriveedhi V, Ramachandran S, Aloush A, Grossman B, Hachem R, Mohanakumar T. (2014) Efficacy of extracorporeal photopheresis in clearance of antibodies to donor-specific and lung-specific antigens in lung transplant recipients. Journal of Heart Lung Transplant ation 33(9): 950-956.
Sarma NJ, Tiriveedhi V, Crippin JS, Chapman WC, Mohanakumar T. (2014) Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis. Journal of Virol ogy 88(7):3733-3743.
Angaswamy N, Klein C, Tiriveedhi V, Gaut J, Anwar S, Rossi A, Phelan D, Wellen JR, Shenoy S, Chapman WC, Mohanakumar T. (2014) Immune responses to collagen-IV and fibronectin in renal transplant recipients with transplant glomerulopathy. American Journal of Transplantation 14(3):685-693.
Amara S, Tiriveedhi V, Tiriveedhi K (2014) Hepatosplenic T-Cell Lymphoma Mimicking Infiltrative Chronic Myelomonocytic Leukemia. Family Medcine & Medical Science Research 3:119 (1-3).
Tiriveedhi V, Gautam B, Sarma NJ, Askar M, Budev M, Aloush A, Hachem R, Trulock E, Myers B, Patterson AG, and T Mohanakumar. (2013) Pre-transplant antibodies to Kα1 tubulin and collagen-V in lung transplantation: Clinical correlations. Journal of Heart Lung Transplantation 32(8):807-814.
Tiriveedhi V, Takenaka M, Sarma NJ, Gelman AE, Patterson GA, and T Mohanakumar. (2013) Anti-major histocompatibility complex-induced obliterative airway disease: Selective role for CD4 and CD8 T cells in inducing immune responses to self-antigens. Journal of Heart Lung Transplantation 32(7):714-22.
Angaswamy N*, Tiriveedhi V*, Sarma NJ, Subramanian V, Klein C, Wellen J, Shenoy S, Chapman WC and T Mohanakumar. (2013) Interplay between Immune responses to HLA and Non-HLA tissue restricted self-antigens in allograft rejection. Human Immunology 74(11): 1478-1485. *Co-first author on this article.
Sarma NJ, Tiriveedhi V, and Mohanakumar T. (2013) Detection of Antibodies to Self-Antigens (K-alpha 1 Tubulin, Collagen I, II, IV, and V, Myosin, and Vimentin) by Enzyme-Linked Immunosorbent Assay (ELISA). Methods Molecular Biology 1034:335-341.
Tiriveedhi V, Fleming TP, Goedegebuure PS, Naughton M, Ma C, Lockhart C, Gao F, Gillanders WE, and T. Mohanakumar. (2013) Mammaglobin-A cDNA vaccination of breast cancer patients induces antigen-specific cytotoxic CD4+ICOShi T-cells. Breast Cancer Research & Treatment 138(1):109-118.
Basha HI, Ramachandran S, Tiriveedhi V, Takenaka M, Nath DS, Benshoff N, Patterson GA, and T Mohanakumar. (2013) Critical role for IL-17A/F in the immunopathogenesis of obliterative airway disease induced by anti-MHC I antibodies. Transplantation 95(2):293-300.
Tiriveedhi V, Takenaka M, Ramachandran S, Gelman AE, Patterson GA, and T Mohanakumar. (2012) T Regulatory cells play a significant role in modulating the MHC Class I antibody Induced Obliterative Airway Disease. American Journal of Transplantation 12 (10): 2663-2674.
Tiriveedhi V, Gelman AE, T Mohanakumar (2012) HIF-1α signaling by airway epithelial cell K-α1-tubulin: Role in fibrosis and chronic rejection of human lung allografts. Cellular Immunology 273(1): 59-66.
Sarma NJ, Tiriveedhi V, Subramanian V, Shenoy S, Crippin J, Chapman W, Mohanakumar T. (2012) Hepatitis C virus mediated changes in microRNA-449a modulate expression of the inflammatory biomarker YKL40 through components of the NOTCH Signaling Pathway. PLOSone 2012; 7(11):e50826.
Sarma NJ, Tiriveedhi V, Ramachandran S, Crippin J, Chapman W, and Mohanakumar T. (2012) Modulation of immune responses following solid organ transplantation by microRNA. Experimental Molecular Pathology 93(3):378-85.
Tiriveedhi V, Sarma NJ, and T. Mohanakumar. (2012) An important role for autoimmunity in the immunopathogenesis of chronic allograft rejection. International Journal of Immunogenetics 39(5): 373-380.
Tiriveedhi V, Angaswamy N, Brand D, Weber J, Hacheem R, Aloush A, Phelan D, Trulock E, Meyers B, Patterson GA, and T Mohanakumar. (2012) Epitope shift of collagen V leads to T-helper switch: Role in chronic lung allograft rejection. Clinical and Experimental Immunology 167(1): 158-168.
Tiriveedhi V, Sarma NJ, Subramanian V, Fleming TP, Gillanders WE, T Mohanakumar. (2012) Identification of HLA-A24 restricted CD8+ Cytotoxic T-Cell Epitopes Derived from Mammaglobin-A, A Human Breast Cancer Associated Antigen. Human Immunology 73(1): 11-16.
Tiriveedhi V, Conzen KD, Liaw-Conlin J, Upadhya G, Malone J, Townsend RR, Kerns R, Jia J, Csontos K, Ramachandran S, Mohanakumar T, Anderson CD, and Chapman WC. (2012) The Role of Molecular Chaperonins In Warm Ischemia and Reperfusion Injury in the Steatotic Liver: A Proteomic Study. BMC Biochemistry 2012, 13(1):17 (1-9).
Takenaka M*, Tiriveedhi V*, Subramanian V, Hoshinaga K, Patterson GA, and T Mohanakumar. (2012) Antibodies to MHC Class II Molecules Induce Autoimmunity: Critical Role for Macrophages in the Immunopathogenesis of Obliterative Airway Disease. PLOS one 2012, 7(8):e42370 (1-11). *Co-first author on this article.
Weber J*, Tiriveedhi V*, Hacheem R, Trulock E, Patterson GA, and T Mohanakumar. (2012) Angiotensin Converting Enzyme inhibitors and Angiotensin Receptor Blockers cause Abrogation of Obliterative Airways Disease in murine model of lung allograft. Journal of Heart Lung Transplantation 31:419-426 . *Co-first author on this article.
Tiriveedhi V, Miller M, Butko P, and Li M. (2012) Autonomous S4 transmembrane segment of voltage sensor domain partitions into the hydrophobic core of the membrane. Biochimica et Biophysica Acta –Biomembranes 1818(7): 1698-1705.
Sarma NJ, Tiriveedhi V, Angaswamy N, and T. Mohanakumar. (2012) Role of antibodies to self-antigens in chronic allograft rejection: potential mechanism and therapeutic implications. Human Immunology 73(12):1275-81.
Hachem RR, Tiriveedhi V, Aloush A, Phelan D, Trulock E, Meyers B, Patterson GA, and T Mohanakumar. (2012) Antibodies to K-α 1 tubulin and collagen V and the impact of their depletion on chronic rejection after lung transplantation. American Journal of Transplantation 12(8):2164-71.
Takenaka M, Subramanian V, Tiriveedhi V, Phelan D, Hachem RR, Trulock E, Gelman AE, Patterson GA, and T Mohanakumar. (2012) Complement activation is not required for obliterative airway disease induced by antibodies to MHC molecules : Implications for Bronchiolitis Obliterans Syndrome following human lung transplantation. Journal of Heart Lung Transplantation 31(11):1214-22.
Nataraju A, Fukami N, Tiriveedhi V, Cianciolo GJ, Chapman WC, and T Mohanakumar. (2012) LMP-420, A Small Molecular Inhibitor of TNF-α, Prolongs Islet Allograft Survival by Induction of Suppressor of Cytokine Signaling-1: Synergistic effect with cyclosporin-A. Cell Transplantation 21(6):1285-96.
Basha HI*, Tiriveedhi V*, Fleming TP, Gillanders WE, Mohanakumar T. (2011) Identification of immunodominant HLA-B7-restricted CD8(+) cytotoxic T cell epitopes derived from mammaglobin-A expressed on human breast cancers. Breast Cancer Research&Treatment 127(1):81-9. *Co-first author on this article.
Tiriveedhi V, Kitchens KM, Nevels K, Ghandehari H, and Butko P. (2011) Kinetic analysis on the interaction of Polyamidoamine (PAMAM) Dendrimers with model lipid membrane. Biochimica et Biophysica Acta - Biomembranes 1808(1):209-218.
Nath DS*, Tiriveedhi V*, Basha HI, Phelan D, Ewald GA, Moazami N, Mohanakumar T. (2011) A role for antibodies to HLA, Collagen-V and K-α1-Tubulin in antibody mediated rejection and cardiac allograft vasculopathy. Transplantation 91(9):1036-1043. *Co-first author on this article.
Subramanian V, Tiriveedhi V, T Mohanakumar. (2011) Biology and function of CD4+regulatory T cells: How close are we to translating into clinical application? American Society of Histocompatibility and Immunogenetics (ASHI) Quarterly 35(4): 18-23.
Subramanian V, Seetharam AB, Vachharajani N, Tiriveedhi V, Angaswamy N, Ramachandran S, Crippin JS, Shenoy S, Chapman WC, T Mohanakumar, Anderson CD. (2011) Donor graft steatosis influences immunity to Hepatitis C virus and allograft outcome following liver transplantation. Transplantation 92(11): 1259-1268.
Saini D, Weber J, Ramachandran S, Phelan D, Tiriveedhi V, Liu M, Steward N, Aloush A, Hachem R, Trulock E, Patterson GA and Mohanakumar T. (2011) Alloimmunity induced autoimmunity as a mechanism in the pathogenesis of chronic rejection of human lung allografts. Journal of Heart Lung Transplantation 30(6):624-631.
Anderson CD, Upadhya G, Conzen KD, Jia J, Brunt EM, Tiriveedhi V, Xie Y, Ramachandran S, Mohanakumar T, Davidson NO, and William C. Chapman WC. (2011) Endoplasmic Reticulum Stress is a Mediator of Post-Transplant Injury in Severely Steatotic Liver Allografts. Liver Transplantation 17(2):189-200 .
Tiriveedhi V, Angaswamy N, Weber J, and Mohanakumar T. (2010) Lipid Raft Facilitated Ligation of K-α1-Tubulin by specific Antibodies on Epithelial cells: Role in pathogenesis of chronic rejection following Human Lung Transplantation. Biochemical Biophysical Research Communications 399(2), 251-255.
Golocheikine A*, Tiriveedhi V*, Angaswamy N, Benshoff N, Sabarinathan R, and Mohanakumar T. (2010) Cooperative signaling for angiogenesis and neovascularization by VEGF and HGF following Islet Transplantation. Transplantation 90(7), 725-731. *Co-first author on this article.
Tiriveedhi V, Weber J, Seetharam A, and Mohanakumar T. (2010) Cross-talk of alloimmune response and autoimmunity: role in pathogenesis of chronic rejection. Discovery Medicine 9(46):229-35.
Seetharam A, Tiriveedhi V, Mohanakumar T. (2010) Alloimmunity and autoimmunity in chronic rejection. Current Opinions in Organ Transplantation 15(4):531-536
Saini D, Angaswamy N, Tiriveedhi V, Fukami N, Ramachandran S, Hachem R, Trulock EP, Meyers B, Patterson A, and Mohanakumar T. (2010) Synergistic effect of antibodies to human leukocyte antigens and defensins in pathogenesis of bronchiolitis obliterans syndrome after human lung transplantation. Journal of Heart Lung Transplantation 29(12), 1330-1336.
Nath DS, Basha HI, Tiriveedhi V, Alur C, Phelan D, Ewald GA, Moazami N, Mohanakumar T. (2010) Characterization of immune responses to cardiac self-antigens myosin and vimentin in human cardiac allograft recipients with antibody-mediated rejection and cardiac allograft vasculopathy. Journal of Heart Lung Transplantation 29(11): 1277-1285.
Tiriveedhi V, and Butko P. (2008) Soluble glycosaminoglycans Inhibit the Interaction of TAT-PTD with Lipid Vesicles. International Journal of Peptide Research & Therapeutics 14(3): 209 – 214.
Lowe A B, Wang R, Tiriveedhi V, Butko P, and McCormick C L. (2007) RAFT Synthesis and Aqueous Solution Properties of pH-Responsive AB Diblock Styrenic-Based Copolymers of 4-Vinylbenzyltrimethylphosphonium Chloride with N,N-Dimethylbenzylvinylamine. Macromolecular Chemistry & Physics 208 (21): 2339-2347.
Tiriveedhi V, and Butko P. (2007) A fluorescence spectroscopy study on the Interactions of the TAT-PTD peptide with model lipid membranes. Biochemistry 46 (12): 3888 – 3895.
Teaching:
BIOL 1010 Introductory Biology I
BIOL 1020 Introductory Biology II
BIOL 1110 General Biology I
BIOL 1120 General Biology II
BIOL 4100 Special Topics
webpage contact:
Biological Sciences