Koen vercruysse

Koen Vercruysse

Dr. Koen Vercruysse

Biochemistry, Pharmacology

Associate Professor

Department of Chemistry


Tennessee State University

3500 John A. Merritt Blvd; Nashville, TN 37209

Phone: (615)-963-5340 Fax: (615)-963-5326 E-mail: kvercruysse@tnstate.edu

1. Education

- University of Ghent, Belgium, B.Sc. 1990, Pharmaceutical Sciences

- University of Ghent, Belgium, Ph.D. 1995, Pharmaceutical Sciences

2. Research and Professional Experience

- 1991: Lab of Galenic Development, Lilly Services S.A., Mont-Saint-Guibert, Belgium

- 1991-1995: Lab of General Biochemistry and Physical Pharmacy, University of Ghent, Belgium; Ph.D. Thesis: “Physico-chemical evaluation of the action of hyaluronidase on hyaluronic acid"

- 1995-1996: Postdoctoral Research Associate, Department of Chemistry, SUNY at Stony Brook, Stony Brook, NY

- 1996-1998: Postdoctoral Research Associate, Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah.

- July 1998-June 2000: Research Assistant Professor, Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah.

- Since August 2000: Assistant/Associate Professor, Department of Chemistry, Tennessee State University, Nashville, Tennessee

3. Publications

1. Dekeyser, P.M., De Smedt, S., Vercruysse, K.P., Demeester, J. and Lauwers, A.R. (1993) High-performance size-exclusion chromatography of proteoglycans extracted from bovine articular cartilage. Anal Chim Acta 279, 123-127.

2. Vercruysse, K.P., Lauwers, A.R. and Demeester, J.M. (1994) Kinetic investigation of the degradation of hyaluronan by hyaluronidase using gel permeation chromatography. J Chromatogr B Biomed Appl 656 (1), 179-190.

3. Vercruysse, K.P., Lauwers, A.R. and Demeester, J.M. (1995) Absolute and empirical determination of the enzymatic activity and kinetic investigation of the action of hyaluronidase on hyaluronan using viscosimetry. Biochem J 306 (Pt 1), 153-160.

4. Vercruysse, K.P., Lauwers, A.R. and Demeester, J.M. (1995) Kinetic investigation of the action of hyaluronidase on hyaluronan using the Morgan-Elson and neocuproine assays. Biochem J 310 (Pt 1), 55-59.

5. Demeester, J. and Vercruysse, K.P. (1997) Hyaluronidase. In Pharmaceutical Enzymes (Lauwers, A. and Scharpe, S., eds.), pp. 155-186, Marcel Dekker.

6. Vercruysse, K.P., Marecak, D.M., Marecek, J.F. and Prestwich, G.D. (1997) Synthesis and in vitro degradation of new polyvalent hydrazide cross- linked hydrogels of hyaluronic acid. Bioconjug Chem 8 (5), 686-694.

7. Van Eeckhout, N., Vercruysse, K., Lauwers, A. and Demeester, J. (1997) Investigation of the activation of hyaluronidase by CaCl2 using viscosimetry and gel-permeation chromatography. Arch. Physiol. Biochem. 105, 133.

8. Prestwich, G.D., Marecak, D.M., Marecek, J.F., Vercruysse, K.P. and Ziebell, M.R. (1998) Chemical modification of hyaluronic acid for drug delivery, biomaterials and biochemical probes. In The chemistry, biology and medical applications of hyaluronan and its derivatives (Vol. 72) (Laurent, T.C., ed.), pp. 43-65, Portland Press.

9. Prestwich, G.D., Marecak, D.M., Marecek, J.F., Vercruysse, K.P. and Ziebell, M.R. (1998) Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives. J Control Release 53 (1-3), 93-103.

10. Prestwich, G.D. and Vercruysse, K.P. (1998) Therapeutic applications of hyaluronic acid and hyaluronan derivatives. Pharm Sci Technol Today 1, 42-43.

11. Vercruysse, K.P. and Prestwich, G.D. (1998) Hyaluronate derivatives in drug delivery. Crit Rev Ther Drug Carrier Syst 15 (5), 513-555.

12. Vercruysse, K.P., Ziebell, M.R. and Prestwich, G.D. (1999) Control of enzymatic degradation of hyaluronan by divalent cations. Carbohydr Res 318 (1-4), 26-37.

13. Prestwich, G.D., Luo, Y., Ziebell, M.R., Vercruysse, K.P., Kirker, K.R. and McMaster, J.S. (1999) Chemically modified hyaluronan: new biomaterials and probes for cell biology". In New Frontiers in Medical Sciences: Redefining Hyaluronan (Abatangelo, G. and Weigel, P.H., eds.), pp. 181-194, Elsevier.

14. Mason, M., Vercruysse, K.P., Kirker, K.R., Frisch, R., Marecak, D.M., Prestwich, G.D. and Pitt, W.G. (2000) Attachment of hyaluronic acid to polypropylene, polystyrene, and polytetrafluoroethylene. Biomaterials 21 (1), 31-36.

15. Vercruysse, K.P., Li, H., Luo, Y. and Prestwich, G.D. (2002) Thermosensitive lanthanide complexes of hyaluronan. Biomacromolecules 3 (4), 639-643.

16. Okorukwu, O.W. and Vercruysse, K.P. (2003) Effects of ascorbic acid and analogs on the activity of testicular hyaluronidase and hyaluronan lyase on hyaluronan. J Enzym Inhib Med Chem 18 (4), 377-382.

17. Jobe, K.L., Odman-Ghazi, S.O., Whalen, M.M. and Vercruysse, K.P. (2003) Interleukin-12 release from macrophages by hyaluronan, chondroitin sulfate A and chondroitin sulfate C oligosaccharides. Immunol Lett. 89(2-3), 99-109.

18. Vercruysse, K.P., Williams, A., Ivory, D., Johnson, B., Dixon, R., Tran, M. and Moore, J. (2007) Using Chondroitin Sulfate to Synthesize Nanoparticles. Proceedings of The Nanotechnology Conference and Trade Show, Santa Clara, May 20-24, Vol 2, 752-755.

19. Vercruysse, K.P., Harper, S.L., Ivory, D.M., Whalen, M.M., Saili, K.S., Tanguay, R.L. (2008) Potential anti-inflammatory properties of biologically-synthesized nanoparticles of gold or silver. Proceedings of The Nanotechnology Conference and Trade Show, Boston, June 1-5, Vol 2, 501-504.

20. Vercruysse, K. P. (accepted) Hyaluronan: a Simple Molecule with Complex Character, in “Renewable Resources for Functional Polymers and Biomaterials” (Williams, P.A., editor), RSC publishing (oxford, UK).

21. Vercruysse, K., Tyler, L., Robinson, S., Ivory,D., Verberne-Sutton, S. and Moore, J. (accepted), Synthesis of gold and silver nanoparticles using chondroitin sulfate and other polysaccharides, in “Advances in Nanotechnology and Applications”.

22. Kadiyala, M., Hatton, W. and Vercruysse, K. (accepted) Polysaccharide-stabilized nanoparticlesas potential drug-carriers. in “Advances in Nanotechnology and Applications”.

23. Stephen, K. and Vercruysse, K. (accepted) Synthesis and characterization of water-compatible noble metal nanoparticles for catalytic applications, in “Advances in Nanotechnology and Applications”.

4. Teaching Experience

- Developed “in-house” laboratory manuals for both “Introduction to General Biochemistry: Laboratory” parts I & II

- Developed and designed new concentration (biochemistry concentration) to Master’s program of Chemistry Department: this new concentration has been approved and helped to boost enrollment numbers to the MS program

- Introduction to General Biochemistry: Part I (lecture and laboratory class)

- Introduction to General Biochemistry: Part II (lecture and laboratory class)

- Advanced Biochemistry: Part II

- Introduction to Pharmacology

- General Chemistry Laboratory

- Introduction to Analytical Chemistry (lecture and laboratory class)

- Special topics: Introduction to Medicinal Chemistry

- Special topics: Introduction to Immunology (undergraduate and graduate class)

- Special topics: Clinical Pharmacology (undergraduate and graduate class)

5. Grant submissions

- “Adsorption of pro-inflammatory cytokines to gold or silver nanoparticles”, submitted Summer 2007 to NIH; budget requested was $302,920; not approved

- “Glycosaminoglycan oligosaccharides and inflammation”, submitted Fall 2007 to NIH; budget requested was $1,219,883; not approved

- “Testing anti-inflammatory properties of nanoparticles of gold generated by cartilage tissue or chondroitin sulfate” subaward proposal to the main proposal “Defining nanomaterial-biological interactions to enhance biocompatibility and biomedical applications” as submitted by collaborators at Oregon State University; budget of subaward requested was $119,352; proposal was approved, but budget had to be amended.

6. Current and Past Service on Departmental, College, University Committees

- Undergraduate curriculum development committee

- Graduate curriculum development committee

- ACS accreditation committee

- Safety Committee

- Instrumentation /Technology Committee

- Search committee for Educational Specialist/Computational Chemistry

- Search committee for Analytical chemist

- Search committee for Chemistry Department head

- Search committee for Inorganic/Organometallic/material science chemist

- Faculty Senator

- Spearheaded the development of the application document for “Signature Status Program” for the Chemistry Department’s Master in Science curriculum; the University’s administration never followed up on their call for these applications.

7. Professional Memberships

- American Chemical Society (ACS)

- American Association for the Advancement of Science (AA

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