Dr. Cosmas Okoro

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Cosmas O. Okoro

Professor

Organic Chemistry

 

Education

North Carolina Central University, Durham, N.C. B.S. (1981), M.S. (1986) - Chemistry

Howard University, Washington, D.C. Ph.D.(1993) - Organic Chemistry

Florida A&M University, Tallahassee, FL Postdoctoral-Fellow (1993-95) - Medicinal Chemistry

University of Kansas, Lawrence, KS Postdoctoral-Fellow (1999-00)- Medicinal Chemistry

Professional Experience

1995-99 Assistant Professor, Dept. of Chemistry, University of Arkansas at Pine Bluff, P

1995-100 Assistant Professor of Chemistry, Tennessee State Univ. Nashville, TN.

2004 – 2009 Associate Professor of Chemistry, Tennessee State University, TN

2009 – 2010 Interim Head of the Department of Chemistry, TSU

2010 –present Professor/Interim Head of the Chemistry Dept., TSU

Ancillary Appointments

1987-88 Teaching Assistant, Dept. of Chemistry, Howard University, Washington, D.C.

1988-93 Graduate Research Assistant, Dept. of Chemistry, Howard University Discovered a new route for the generation of a silyl anion, a useful reagent for silicon-carbon bond formation.

1993-95 Research Associate, Florida A&M University College of Pharmacy and Pharmaceutical

Sciences, Tallahassee, Fl. Designed, synthesized, and characterized several N-Phenylcarbonyl amino-1,2,3,6-tetrahydropyridines as potential anti-inflammatory agents.

1999- NIH Fellow, Dept. of Medicinal Chemistry, University of Kansas, Lawrence. Synthesized and characterized 7-N-ethylaminosulfonyl-3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline as inhibitors of Phenylethanolamine N-Methyltransferase versus 2-adrenoceptor.

Professional Affiliations

American Chemical Society, 1985-present

Sigma Xi Scientific Research Society

Phi Lambda Upsilon Honorary Chemical Society

Beta Kappi Chi Scientific Honor Society

New York Academy of Sciences

International Who’s Who of Professionals

Tennessee Academy of Science

Tennessee Cancer Coalition

American Association of Pharmaceutical Scientists

Other Activities/Awards

Who’s Who Among students in American Colleges and Universities

Recipient FASEB/MARC Travel Award

Certificate of Appreciation Tennessee State University 22nd Annual University Wide Research Symposium

Certificate of Recognition Tennessee State University 23rd Annual University Wide Research Symposium

Founder, American Chemical Society-University of Arkansas at Pine Bluff Student Affiliate Chapter

Faculty mentor Delta Sigma Theta Sorority Scholar-University of Arkansas at Pine Bluff

Faculty mentor American Chemical Society Minority Scholar Program (Mario Curtis)-Tennessee State University.

Chair-Elect American Chemical Society, Nashville Local Section, 2002

Chair – ACS Nashville Local Section, 2003

Certificate of Recognition as Judge – Annual Minority Biomedical Research Conference, New Orleans, 2002

Certificate of Participation – Workshop on High Performance Computing for Minority- Serving Institutions, Atlanta, 2002

Participant National Science Foundation (NSF) Undergraduate Research Summit, Bates College, Portland, ME, August 2-4, 2003.

Committee Appointments (University of Arkansas at Pine Bluff)

Recruitment committee (1995-99)

Facility Committee, School of Science and Technology (1995-97)

Chairperson, Facilities committee, School of Arts and Sciences (1998-99)

Founder’s day Committee (1996-99)

Faculty/Staff Budget Committee (1998-99)

Committee Appointments (Tennessee State University)

Faculty Advisor Chemistry Club (1999-2006)

Undergraduate Curriculum Committee, Chemistry Dept. (1999-00)

Instrumentation Committee, Chemistry Dept. (1999-00)

Undergraduate Recruitment/Retention Committee, Chemistry Dept. (1999-00)

Chair Organic Chemistry Faculty search committee (1999-00)

Chair Undergraduate Curriculum Committee (2000-01)

Instrumentation Committee (2000-01)

Search Committee faculty position-Computational Chemistry/Chemical Education (2002)

Graduate Committee, Chemistry Dept.( 2000-present)

Search Committee for a permanent Chair Dept. of Chemistry (2002-present).

Chair, Graduate Committee, Dept. of Chem. (2002-present)

Member of the Graduate Council-Tennessee State University (2002-present)

Member, Tenure and promotion Committee, College of Arts and Sciences, (2005-2006)

Member, Tenure and promotion Committee, College of arts and Sciences (2006-2007)

Member, tenure and promotion Committee, College of Agriculture and Consumer Sciences (2009-2010)

Member, Dept. Committee for Recruitment/Outreach/Fund-Raising/Alumni(2004-2005)

Member, Tenure and Promotion Committee, Dept. of Chemistry, 2005 -2006

Member, Undergraduate Curriculum Committee, Dept. of Chemistry, 2006-2007

Member, Graduate Council Committee, TSU 2006-2007

Chair, Book Adoption Committee-Department of Chemistry, Spring 2008 -

Graduate Coordinator – Chemistry (2002-present)

TSU – Vanderbilt Minority Bridges Program Coordinator

Member, search committee-dean of graduate school

Chair, tenure and promotion committee, Dept. of Chemistry -2008

Interim Head of Chemistry-July 2009 -August 2011

Chair –faculty search committee, Dept. of Chemistry –Spring Semester 2009.

Book Review

Chemistry for the Health Sciences, George I. Sackheim and Dennis D. Lehman, 8th Ed. Prentice Hall Publishing, 1997.

Undergraduate Students Mentored – Senior Projects

1999-00 Lori M. Ward ( B.S.), Keely S. Jones, (B.S.), David G. Jones,( B.S); Lakeisha Williams (B.S.), Mario Curtis (B.S.)

2002-03 Clarice Salone (B.S.), Stephen Nuyong (B.S.)

2004-05 Candice Griffin (B.S.), Morgan Lorch (B.S.), Sonya Smith (B.S.)

2005-06 Carolyn Cummings (B.S.), Lena A. Do (BS), Asefa Seyoum (BS)

2006-07 Jasmine Johnson (BS), Kendra Wash (BS), Andrea Mitchelle (BS), Ashley Williams (BS); Krishna Stephens(BS)

2007-08 Lashaya Ruffin (BS); Lolade Akinola (BS); Terrence Qualls (BS).

2008-09 Jarvis Calcutta (B.S. 2010); Falkanaz Gundi (B.S. -ACS); Deanna Bogan (progress)

2009-10 Ijeoma V. Chimezie (progress)

Thesis Advisor

2000 -03 Patrice Jackson: Fluorinated Enaminone Benzamides, MS Thesis May 2003; Ph.D Howard University, Assistant Professor, University of Maryland Eastern Shore.

2000-03 Jessica L. Gadsden: Clozapine Induced Internalization and Desensitization of the 5-HT2C Receptor, MS Thesis July 2003; Ph.D. student at Meharry Medical College,  Nashville, TN.

2003-05 Takeisha Farmer, former Graduate Student, Dept. of Chemistry – PhD student Purdue University-Indiana University at Indianapolis.

2003-05 Rhonda Richmond, M.S. Thesis (2005) “Synthesis, Conformational Analysis, and Molecular Properties of Fluorinated Enaminones,

2005-2007 M.S. Thesis (2007), Olugbeminiyi O. Fadeyi, Fluorinated Building Blocks-Valuable Therapeutics”. Ph.D. student Vanderbilt University Department of Chemistry.

2007- 2009 M.S. Thesis (2009), Oloropo C. Agbaje, Lewis acid mediated diastereoselective synthesis of fused fluorinated spiroketal as potential biologically active unnatural products.

2008- 2010 Otome E. Okoromoba, Synthesis and structure activity relationship of Fluorinated Enaminone Derivatives, Ph.D. student University of Kenturky-Louisville

2009- Mumiye Ogunwale, Synthesis and Characterization of Fluorinated Hexahydroquinolines, as potential biologically active compounds –progress

2009- Hadijatu Kamara, Synthesis of fluorinated Triketones and Indolones – progress

2010- Adeayo Ajala –Computational Chemistry/Organic Synthesis - progress

Former Students Who have Completed Doctoral or professional Degrees

Patrice L. Jackson – PhD. Howard University, 2010; Assistant Professor of Medicinal Chemistry-University of Maryland, Eastern Shore, MD

Lori Ward – Ph.D. Purdue University, 2010

Carolyn Cummings, PharmD. University of TN Health Science Center, Memphis

Olugbeminiyi O. Fadeyi – Ph.D. (Chemistry)-Vanderbilt University, June 2011.

Research grant Proposals Submitted/Funded

NIH U 54 Cancer Partnership: Synthesis, SAR and Mechanisms of TSUA-58 as small molecule inhibitor of EZH2 submitted in January 2014 by Chen, Matusik and Okoro, $250,000 – not funded.

2 U54 MD007593-06: Mehary Clinical and Translational Research Center (MeTRC): pilot project: Explorations on the Anticancer Efficacy of Novel Acridone Derivatives; PI-Adunyah Samuel; Co-PIs: Chen, Okoro, and Lu. $220,000. Status: Funded

NIH/MBRS 08211-06, 1997; Synthesis and Anticonvulsant Activity of Substituted isoxazolyl, pyrazolyl, thiazolyl and thiadiazolyl enaminone ester derivatives: total direct cost $424,135.00 – not funded

NIH/MBRS S06, 1998; Synthesis and anticonvulsant Activity of 2-Carbethoxymethyl Anilines: total direct cost $75,000.00 – not funded NIH/ HL34193-13, 1999; Design and synthesis of inhibitors of Epinephrine Biosynthesis: total direct cost $58,720.00 - funded

Summer Chemistry Enrichment program for talented High School students in Nashville School District – Submitted to Camille and Henry Dreyfus Foundation Special Grant program in the Chemical Sciences, August 2000; total direct cost $16,500.00 – not funded

Faculty Initiation/Enhancement Program-EARDA Component, 1999, Design and synthesis of Fluorinated Enaminones: total direct cost $7,000.00 -funded

09/30/2002 – 08/31/2005: R25 GM60190-02 Minority Bridges Program, PI: LJ DeFelice, Co-Investigator, C. O. Okoro (5%), Direct costs $714,000 Barry University, Clark Atlanta, Florida A&M University, Tuskegee University, Tennessee State University, University of Puerto Rico at Mayaguez, Fisk University, and Vanderbilt University have joined in an initiative to increase the number of underrepresented minorities entering careers in biomedical research. The program joins universities offering the M.S. in the sciences to Vanderbilt University offering the Ph.D. The goal is to improve the competitiveness of underrepresented minorities and facilitate their transition into biomedical research; Status: Funded.

NIH/MBRS SCORE, February 2002: Synthesis of Fluoxetine Analogs: Conformational restriction with substituted phenoxy-2,3,4,5-tetrahydro-1H-2-benzazepines,

PI: Cosmas O. Okoro, (33%), Direct cost $379,229.00 – not funded

Faculty Initiation/Enhancement Program-RISE Component, 2002, Design and synthesis of Fluorinated Enaminones: total direct cost $5,500.00 - funded

NSF 02-111- CAREER, 2003: Synthesis and Utilization of Fluorinated Enaminones; total direct cost $455,408.00; period covered: 5/04-5/09- not funded

NSF 05515 – 2005; Acquisition of 400 MHz NMR Spectrometer: total cost $219,900.00 – not funded

09/30/2006 – 08/31/2009: R25 GM60190-02 Minority Bridges Program, PI: LJ DeFelice, Co-Investigator, C. O. Okoro (5%), Direct costs $607,813 Barry University, Florida A&M University, IIinois State University, Tennessee State University, University of Puerto Rico at Mayaguez, Fisk University, and Vanderbilt University have joined in an initiative to increase the number of underrepresented minorities entering careers in biomedical research. The program joins universities offering the M.S. in the sciences to Vanderbilt University offering the Ph.D. The goal is to improve the competitiveness of underrepresented minorities and facilitate their transition into biomedical research – funded

Publications/Presentations

1. Jongoh Choi, Tiffany L. Wilson, Ana M. Ly, Cosmas O. Okoro, Udobi C. Onubogu, and Kinfe K. Redda, “Synthesis of Some N-(phenylsulfonylamino)-1,2,3,6-Tetrahydropyridines as Potential Anti-inflammatory Agents.” Med. Chem. Res. 1995, 5, 281-295.

2. Clanicia A. Pelle, Cosmas O. Okoro, Tiffany L. Wilson, Udobi C. Onubogu, Kyoung-Jin Yoon, and Kinfe K. Redda, ‘Synthesis of Several N-(Substituted Phenylcarbonylamino)-4-(3-Cyclohexenyl)-1,2,3,6-Tetrahydropyridines as potential Anti-inflammatory Agents.” Synth. Commun. 1996, 26(14), 2703-2714.

3. Cosmas O. Okoro, Tiffany L. Wilson, Jongoh Choi, and Kinfe K. Redda, “Synthesis and Antiinflammatory Activity Determination of Some N-(Substituted Phenylcarbonylamino)-4-(1-Hydroxymethylphenyl)-1,2,3,6-Tetrahydropyridines, Med.Chem. Res. 1997, 7(1), 1-15.

4. Y.M. Hiiji, P.F. Hudrlik, C.O. Okoro, and A.M. Hudrlik. “Preparation of O-(Silyl)Benzyl Alcohols” Synth. Commun. 1997, 27, 4297-4308

5. CosmasO.Okoro, Kyoung Jin P.Yoon, Tiffany L. Wilson, Udobi C. Onubogu, Tanya S. Eckford and Kinfe K. Redda. “Synthesis and Biological Evaluation of N-(Substituted Benzoylamino)-5-carbethoxymethyl -1,2,3,6-Tetrahydropyridines as Potential Anti-inflammatory and Hyperglycemic Agents.” Med. Chem. Res. 1999, 9(2) 133-148.

6. P.F. Hudrlik, J.O. Arango, Y.M. Hijji, C.O. Okoro and A.M. Hudrlik. “Alkoxides of O-Silyl Benzyl Alcohols in Cleavage Reactions: Approaches to Benzyl and Silyl Anion Equivalents.” Can. J. Chem. 2000, 78, 1421-1427

7. P.F. Hudrlik, C.O. Okoro, and A.M. Hudrlik. “Generations of a Silyl Anion Equivalent by Intramolecular Alkoxide Attack at Silicon.” NIGMS Symposium 1991, 483, 130.

8. P.F. Hudrlik, Y.M. Abdallah, C.O. Okoro and A.M. Hudrlik.” Rearrangemnet of Organosilicon Compounds.” ACS Symposium Series 1992, 242.

9. P.F. Hudrlik, Y.M. Abdallah, C.O. Okoro and A.M. Hudrlik. “ Benzyloxysilanes Cleavage and Rearrangement Reactions.” XXVII Organosilicon Symposium 1993, G10.

10. C. A. Pelle, C.O. Okoro, T.L. Wilson, U.C. Onubogu, K.J. Yoon, and K.K. Redda. “ Synthesis and Characterization of Several N-(Substituted Phenylcarbonylamino)-4-Cyclohexenyl-1,2,3,6-Tetrahydropyridines.” NIGMS Symposium 1995, A-11, 5.

11. C.O.Okoro, U.C. Onubogu, T.S. Eckford, C.A. Pelle, T.L. Wilson and K.K. Redda. “The Synthesis and Biological Evaluation of N-(Substituted-Phenylcarbonylamino)-3-Carboethoxymethyl-1,2,3,6-Tetrahydropyridine as Potential Anti-inflammatory and Hyperglycemic Agents.” 210th ACS National Meeting, Chicago, Aug.20-24, 1995, MEDI 90.

12. C.O. Okoro, T.L. Wilson, J. Choi and K.K. Redda. “ Synthesis of N-(Substituted –Phenylcarbonylamino)-4-(1-Hydroxymethylphenyl)-1,2,3,6-Ttrahydropyridines as Potential Hyperglycemic and Anti-inflammatory Agents. NIGMS Symposium 1995, A-12, 5.

13. C.O.Okoro. “The Role of Chemistry and Chemicals in Health and Medicine.” University of Arkansas Pine Bluff-National Center for Toxicological Research Biomedical Seminar Series, April 13, 1998.

14. C.O.Okoro and G.L. Grunewald. “Synthesis of 7-N-ethylsulfonyl-1,2,3,4-tetrahydroisoquinoline as Selective Inhibitor of Phenylethanolamin-N-Methyltransferase (PNMT) versus 2 –Adrenoceptor Affinity.” 23rd Annual Research Symposium, Tennessee State University, March 20-21, 2001.

15. Patrice Jackson and C. O. Okoro. “ Fluorinated Enaminones as reactive intermediates in Organic Synthesis.” 24th Annual Research Symposium, Tennessee State University, March 19-20, 2002.

16. Cosmas O. Okoro, Tifanny L. Wilson, and Kinfe K. Redda. “Conformational Analysis and Molecular Properties of N-(Substituted Phenylcarbonylamino)-4-(1-hydroxymethylphenyl)-1,2,3,6-tetrahydropyridines, Current Medicinal Chemistry, 2003, 10. 313-320.

17. Cosmas O.Okoro and Patrice L. Jackson, “Synthesis, Conformational Analysis and Molecular Properties of New Trifluoromethyl Enaminone”, Abstracts, 55th Southeast Regional Meeting of the American Chemical Society, Atlanta, GA, United States, November 16-19, 2003 (2003), 565. Publisher, American Chemical Society, Washington, D.C. CODEN: 69EUCH Conference; Meeting Abstract written in English. AN2004: 129444. CAPLUS (Copyright 2004 ACS on SciFinder(R)).

18. Jessica Gadsden, Elaine Sanders-Bush, and Cosmas Okoro, “Acute Clozapine exposure does not desensitize 5-HT2C Receptors in vitro”, Abstracts, 55th Southeast Regional Meeting of the American Chemical Society, Atlanta, GA, United States, November 16-19, 2003 (2003), 167. Publisher, American Chemical Society, Washington, D.C. CODEN: 69EUCH Conference; Meeting Abstract written in English. AN2004: 132310. CAPLUS (Copyright 2004 ACS on SciFinder(R)).

19. Farmer, Takeisha L.; Okoro, Cosmos O. “Synthesis, Comformational Analysis, and Molecular properties of Methyl 4-[(Substituted phenyl)amino]-2-oxo-6-trifluoromethyl)cyclohex-3-ene-1-oates” Abstracts, 57th Southeast/61st Southwest joint Regional Meeting of the American Chemical Society, Memphis, TN, United States, November 1-4 (2005), NOV04-415: Publisher: American Chemical Society, Washington, D. C. CODEN: 69 HOKM Conference; Meeting Abstract written in English. AN 2005:1225106 CAPLUS (Copyright(C)2005 ACS on ScFinder (R))

20. Brown, Patrick; Okoro, Cosmos O. “Pharmacophore Analysis of hSert and hNet inhibitors” Abstracts, 57th Southeast/61st Southwest joint Regional Meeting of the American Chemical Society, Memphis, TN, United States, November 1-4 (2005), NOV04-402: Publisher: American Chemical Society, Washington, D. C. CODEN: 69HOKM Conference; Meeting Abstract written in English. AN 2005:1225093 CAPLUS (Copyright(C)2005 ACS on ScFinder (R))

21. Gary L. Grunewald, Jian Lu, Kevin R. Criscione and Cosmas O. Okoro, Inhibitors of phenylethanolamine N-methyltransferase devoid of α2 –adrenoceptor affinity. Bioorganic & Medicinal Chemistry Letters 15 (2005) 5319-5323.

22. Cosmas O. Okoro, Olugbeminiyi O. Fadeyi, Patrice L. Jackson, Rhonda L. Richmond, and Takeisha Farmer, Synthesis of fluorinated cyclic s-trans vinylogous acid and amide ester derivatives. Tetrahedron Letters 47 (2006) 7451-7454.

23. Olugbeminiyi O. Fadeyi, and Cosmas O. Okoro, “Synthesis and reactions of Fluorinated Cyclic s-Trans Vinylogous acids and Amides: Palladium-catalyzed coupling of fluorinated cyclic s-trans enaminone with aryl and heteroaromatic halides”. Journal of the Tennessee Academy of Science, Vol 81, No. 3-4, page 88 (2006).

24. Saudat T. Adamson, Olugbeminiyi O. Fadeyi, Elber L. Myles and Cosmas O. Okoro, “The anticancer effects of some West African medicinal plants”. Journal of the Tennessee Academy of Science, Vol 81, No. 3-4, page 89 (2006).

25. Olugbeminiyi O. Fadeyi, Carolyn Cummings, Saudat T. Adamson, Cosmas O. Okoro, and E. Lewis Myles, “Isolation and characterization of the active components of Setaria Megaphylla”. Journal of the Tennessee Academy of Science, Vol 81, No. 3-4, page 89 (2006).

26. Fadeyi, Olugbeminiyi O.; Wash, Kendra; Okoro, Cosmas O.. Synthesis of fluorinated dihydropyrazolo-pyrimidine

derivatives as potential biologically active compounds. Abstracts of Papers, 233rd ACS National Meeting,

Chicago, IL, United States, March 25-29, 2007 (2007), MEDI-408. CODEN: 69JAUY AN 2007:295837 CAPLUS

27. Olugbeminiyi O. Fadeyi, Cosmas O. Okoro. Synthesis of 5-(trifluoromethyl)cyclohexane-1,3-dione and 3-amino-5-(trifluoromethyl)cyclohex-2-en-1-one: new trifluoromethylbuilding block. Tetrahedron Lett. 49 (2008) 4725-4727.

28. Olugbeminiyi O. Fadeyi, Saudat T. Adamson, E. Lewis Myles, Cosmas O. Okoro. Novel fluorinated acridone derivatives. Part 1: Synthesis and evaluation as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters 18 (2008) 4172-4176.

29. Oluropo C. Agbaje, Olugbeminiyi O. Fadeyi, S. Adamson Fadeyi, Lewis E. Myles, Cosmas O. Okoro. Synthesis and in vitro cytotoxicity of some fluorinated hexahydropyrimidine derivatives. Bioorganic & Medicinal Chemistry Letters 21 (2011) 989-992.

30. Ogunwale, Mumiye A.; Okoro, Cosmas C. Synthesis of novel trifluoromethylated hexahydroquinoline derivatives as potential calcium channel modulators. Abstracts of Papers, 241st ACS National Meeting & Exposition, Anaheim, CA, United States, March 27-31, 2011 (2011), MEDI-142. CODEN: 69NZUR. AN 2011:338179 CAPLUS (Copyright © 2011 ACS on SciFinder ®

31. Mumini, Hadijatu; Okoro, Cosmas. Synthesis and antitumor activity evaluation of some trifluoromethylated indolones. Abstracts of Papers, 241st ACS National Meeting & Exposition, Anaheim, CA, United States, March 27-31, 2011 (2011), ORGN-735. CODEN: 69NZUR. AN 2011:339200 CAPLUS (Copyright ©2011 ACS on SciFinder ®

32. Cosmas O. Okoro, Tasneem Siddiquee, and Olugbeminiyi O. Fadeyi. 5,7-Dibromo-3-trifluoromethyl-3,4-dihydroacridin-1 (2H)-one.Acta Cryst. (2011). E67, o2052

33. Oluropo C. Agbaje, Olugbeminiyi O. Fadeyi, Cosmas O. Okoro. Lewis acid mediated diastereoselective synthesis of fused fluorinated spiroketal as potential biologically active compounds. Tetrahedron Letters 52 (2011) 5297-5300.

34. Adeayo O. Ajala, Cosmas O. Okoro. CoMFA and CoMSIA studies on fluorinated hexahydropyrimidine derivatives. Bioorganic & Medicinal Chemistry Letters 21 (2011) 7392-7398.

35. Cosmas O. Okoro, Mumiye A. Ogunwale and Tasneem Siddiquee. Synthesis of Some new fluorinated hexahydroquinoline and acridinedione derivatives in trifluoroethanol. Appl. Sci 2012, 2, 368-374

36. Mumini, Hadijatu; Okoro, Cosmas .  Synthesis and antitumor activity evaluation of some trifluoromethylated indolones.  Abstracts of Papers, 241st ACS National Meeting & Exposition, Anaheim, CA, United States, March 27-31, 2011 (2011), ORGN-735. CODEN: 69NZUR. AN 2011:339200 CAPLUS (Copyright ©2011 ACS on SciFinder ®

37. Cosmas O. Okoro , Tasneem Siddiquee, and Olugbeminiyi O. Fadeyi. 5,7-Dibromo-3-trifluoromethyl-3,4-dihydroacridin-1 (2H)-one.Acta Cryst. (2011). E67, o2052

38. Oluropo C. Agbaje, Olugbeminiyi O. Fadeyi, and Cosmas O. Okoro, “Lewis Acid Mediated Diastereoselective Synthesis of Fused Fluorinated Spiroketal as potential Biologically Active Compounds. Tetrahedron Letters (2011), doi: 10.1016/j.tetlet.2011.08.004.

39. Adeayo O. Ajala and Cosmas o. Okoro , “CoMFA and CoMSIA studies on fluorinated hexahydropyrimidine derivatives”. Bioorganic & Medicinal Chemistry Letters 21 (2011) 7392-7398.

40. Saudat A. Fadeyi, Olugbeminiyi O. Fadeyi, Adedeji A. Adejumo, Cosmas O. Okoro and Elbert L. Myles, In Vitro anticancer screening of 24 locally used Nigerian medicinal plants, BMC Complementary and Alternative Medicine 2013, 13:79

41. Cosmas O. Okoro , John Apraku, Elisha Okoromoba, and Olugbeminiyi O. Fadeyi, Synthesis and Anticonvulsant Activity of Fluorinated Cyclic Enaminones.  Letters in Drug Design & Discovery, 2013, 10, 1024-1031.

42. Gipson, Shondra N.; Okoro, Cosmas O. C-acylation of 5-trifluoromethyl-1,3-cyclohexanedione with substituted unactivated carboxylic acids and benzoyl chlorides.  Abstracts of Papers, 247th Americcan Chemical Society (ACS) National Meeting and Exposition, Dallas, TX, United States, March 16-20, 2014-ORGN-495.

 






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