Dr. Cosmas Okoro

Dr. Okoro's Profile Picture

Cosmas O. Okoro
Professor of Chemistry
College of Life and Physical Sciences


Contact Information:
Office Location: Boswell Sc. Complex Room 211
Telephone: 615-963-5332
FAX: 615-963-5326
Email: cokoro@tnstate.edu

Research Areas:
Synthetic Organic & Medicinal Chemistry
Computational Chemistry & Molecular Modeling


  • General, Organic and Biochemistry (GOB)
  • Organic Chemistry
  • Medicinal Chemistry
  • Biochemistry
  • Scientific Communication
  • Advanced Organic Chemistry part A
  • Special Topic – Natural Products


Refereed Journal Articles: 16
Journal Citations: 6
Research Abstracts: 15
Conference Presentations: 15


  1. Obi, Chibuike D.; Okoro, Cosmas O . Synthesis of 5-(trifluoromethyl)cyclohexane-1,2,3-trione (cVTC):new trifluoromethyl building block. Tetrahedron Letters (2016), 57(47), 5259-5261. 
  2. Infante Lara, Lorena; Sledge, Alexis; Laradji, Amine; Okoro, Cosmas O .; Osheroff, Neil. Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1 (2H)-ones act as topoisomerase Iiα poison. Bioorganic & Medicinal Chemistry Letters (2017), 27(3), 586-589.
  3. Olugbeminiyi O. Fadeyi, Cosmas O. Okoro . Synthesis of 5-(trifluoromethyl)cyclohexane-1,3-dione and 3-amino-5-(trifluoromethyl)cyclohex-2-en-1-one: new trifluoromethylbuilding block. Tetrahedron Lett. 49 (2008) 4725-4727.
  4. Olugbeminiyi O. Fadeyi, Saudat T. Adamson, E. Lewis Myles, Cosmas O. Okoro. Novel fluorinated acridone derivatives. Part 1: Synthesis and evaluation as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters 18 (2008) 4172-4176.
  5. Oluropo C. Agbaje, Olugbeminiyi O. Fadeyi, S. Adamson Fadeyi, Lewis E. Myles, Cosmas O. Okoro . Synthesis and in vitro cytotoxicity of some fluorinated hexahydropyrimidine derivatives. Bioorganic & Medicinal Chemistry Letters 21 (2011) 989-992.
  6. Ogunwale, Mumiye A.; Okoro, Cosmas C . Synthesis of novel trifluoromethylated hexahydroquinoline derivatives as potential calcium channel modulators.  Abstracts of Papers, 241st ACS National Meeting & Exposition, Anaheim, CA, United States, March 27-31, 2011 (2011), MEDI-142. CODEN: 69NZUR.  AN 2011:338179 CAPLUS (Copyright © 2011 ACS on SciFinder ®
  7. Mumini, Hadijatu; Okoro, Cosmas .  Synthesis and antitumor activity evaluation of some trifluoromethylated indolones.  Abstracts of Papers, 241st ACS National Meeting & Exposition, Anaheim, CA, United States, March 27-31, 2011 (2011), ORGN-735. CODEN: 69NZUR. AN 2011:339200 CAPLUS (Copyright ©2011 ACS on SciFinder ®
  8. Cosmas O. Okoro , Tasneem Siddiquee, and Olugbeminiyi O. Fadeyi. 5,7-Dibromo-3-trifluoromethyl-3,4-dihydroacridin-1 (2H)-one.Acta Cryst. (2011). E67, o2052
  9. Oluropo C. Agbaje, Olugbeminiyi O. Fadeyi, and Cosmas O. Okoro, “Lewis Acid Mediated Diastereoselective Synthesis of Fused Fluorinated Spiroketal as potential Biologically Active Compounds. Tetrahedron Letters (2011), doi: 10.1016/j.tetlet.2011.08.004.
  10. Adeayo O. Ajala and Cosmas o. Okoro , “CoMFA and CoMSIA studies on fluorinated hexahydropyrimidine derivatives”. Bioorganic & Medicinal Chemistry Letters 21 (2011) 7392-7398.
  11. Saudat A. Fadeyi, Olugbeminiyi O. Fadeyi, Adedeji A. Adejumo, Cosmas O. Okoro and Elbert L. Myles, In Vitro anticancer screening of 24 locally used Nigerian medicinal plants, BMC Complementary and Alternative Medicine 2013, 13:79
  12. Cosmas O. Okoro , John Apraku, Elisha Okoromoba, and Olugbeminiyi O. Fadeyi, Synthesis and Anticonvulsant Activity of Fluorinated Cyclic Enaminones.  Letters in Drug Design & Discovery, 2013, 10, 1024-1031.
  13. Gipson, Shondra N.; Okoro, Cosmas O. C-acylation of 5-trifluoromethyl-1,3-cyclohexanedione with substituted unactivated carboxylic acids and benzoyl chlorides.  Abstracts of Papers, 247th Americcan Chemical Society (ACS) National Meeting and Exposition, Dallas, TX, United States, March 16-20, 2014-ORGN-495.


CHEM 1100/CHEM 1101 – Fundamental of Organic & Biochemistry Lecture/Lab
CHEM 2010/2011 - Organic Chemistry I Lecture/Lab
CHEM 2020/2021 – Organic Chemistry II Lecture/Lab
CHEM 4100 – Scientific Communication
CHEM 4420 – Introduction to Medicinal Chemistry
CHEM 5210 – Advanced Organic Chemistry

Professional Affiliations:
American Chemical Society Division of medicinal Chemistry
Sigma Xi Scientific Research Society
Phi Lambda Upsilon Honorary Chemical Society
Beta Kappa Chi Scientific Honor SocietyAmerican Association of Pharmaceutical Scientists
Tennessee Cancer Coalition
International Who’s Who of Professionals
Chair, Nashville section of the American Chemical Society
Tennessee Academy of Sciences

B.S. Chemistry (1981) –North Carolina Central University, Durham, N. C.
M.S. Organic Chemistry (1986) –North Carolina Central University, Durham, N. C.
Ph.D. Organic Chemistry (1993) –Howard University, Washington, DC
Postdoctoral Research Associate, (1993-1995), Florida A & M College of Pharmacy and Pharmaceutical Sciences
NIH Fellow in Medicinal chemistry (1999-2000), University of Kansas, Lawrence, KS

Detailed CV

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