Mohammad Karim

student on campusMohammad Karim, Ph.D. - Organic Chemistry

Professor and Chair

Department of Chemistry

 

 

EDUCATION:

• Ph.D. Kent State University (Org. Chemistry), Kent, Ohio, 1989

• M.Sc. Jahangirnagar University (Org. Chemistry), Dhaka, Bangladesh, 1980

• B.Sc.(Hons) Jahangirnagar University (Chemistry), Dhaka, Bangladesh.

• Graduate Faculty since 1994

TEACHING AND ADMINISTRATIVE EXPERIENCES:

• Professor and Chair: (August 2011-Present), Department of Chemistry, Tennessee State University, Nashville, Tennessee

• Associate Dean (Interim): (July 2009-2011), School of Graduate Studies and research, Tennessee State University, Nashville, Tennessee

• Professor and Chair: (August 2003-June 2009), Department of Chemistry, Tennessee State University, Nashville, Tennessee

• Associate Professor: (August 1998-July 2003), Department of Chemistry, Tennessee State University, Nashville, Tennessee

• Assistant Professor: (August 1994-July 1998), Department of Chemistry, Tennessee State University, Nashville, Tennessee

• Assistant Professor: (August 1992-August 1994), Division of Science and Mathematics, Rust College, Holly Springs, Mississippi. Adjunct Faculty, LeMoyne-Owen College, Memphis, Tennessee

• Postdoctoral Research Associate: (September 1990-August 1992), Department of Chemistry, Georgia State University, Atlanta, Georgia

• Postdoctoral Research Associate: (September 1989-August 1990), Institute of Paper Science and Technology (IPST), Atlanta, Georgia.

• Teaching Assistant: (1985-89), Kent State University, Kent, Ohio.

• Lecturer in Chemistry: (1980-84), Bangladesh University of Engineering and Technology, Dhaka, Bangladesh.

• Teaching Assistant: (1979-80), Jahangirnagar Univ., Bangladesh.

COURSES TAUGHT

• CHEM 1110-General Chemistry I

• CHEM 2010-Organic Chemistry I

• CHEM 2020-Organic Chemistry II

• CHEM 3005-Organic Chemistry Survey

• CHEM 4100-Scientific Communications

• CHEM 4600 & 5600-Spectroscopic Methods – Graduate and Undergraduate

• CHEM 6408-Special Topics Organic – Retrosynthetic Analysis

OTHER RESPONSIBILITY

Chair, University Biosafety Committee since 1997

Radiation Safety Officer since 2000

RESEARCH SKILLS

Method Development:

Highly experienced in developing variety of analytical methods using mass spectrometry, HPLC and GC. Highly experienced with multinuclear high field NMR, FT-IR, HPLC, UV-VIS to characterize new compounds. Extensive experiences in Modern Chromatographic Techniques.

Synthetic:

Experienced in the synthesis of the basic skeleton of the anticancer drug –Taxol, Developed a novel synthesis of macrocyclic ketolactones. Synthesized a large number of compounds as potential as anti-AIDS drugs. Carried out initial evaluation of these potential drugs. Experienced in the synthesis of neurotransmitter agents. Experienced in dealing with extremely moisture sensitive compounds. Have extensive experiences in micro and macro scale reactions. Experienced in carrying out low temperature reactions

PROFESSIONAL TRAINING

• “A Year-Long Workshop on Academic Leadership organized by Regents Academic Leadership Institute (RALI)” July 2005-May 2006.

• “Teaching Chemical Information: Tips and Techniques”, ACS Sponsored Workshop to learn about techniques and resources for teaching chemical information, April 13-17, San Francisco, CA.

• “NIH Grant Writing Workshop” Dr. James G. Townsel, NIH Review Consultant and Director of Neuroscience at Meharry Medical College, Tennessee State University, October 26, Room 319 Floyd-Payne Campus Center, 1996.

• “Molecular Modeling in the Undergraduate Curriculum” Wavefunction, Inc., Tennessee State University, Department of Chemistry, February 2001.

• Radiation Safety Officer Training Course (40 Hour Course), CSI-Radiation Safety Academy, Gaithersburg, Maryland, May 20-24, 2002

• DOT Training Requirements for Shipping and Receiving Radioactive Materials, CSI-Radiation Safety Academy, Gaithersburg, Maryland, May 20-24, 2002

• Training on Radiation Instruments: Test and Calibration (20 Hour Course), Nevada Technical Associates, Inc. July 22-24, 2002

CURRENT RESEARCH PROJECTS:

Areas Of Interest

Synthetic organic chemistry, development of new synthetic strategy, natural product synthesis, synthesis of anticancer and anti-AIDS agents.

• Synthesis of Schiff’s Bases

• Synthesis of Curcumol and Related Natural products

• Synthesis of Cembranoid Diterpenes

HONORS AND AWARDS:

• An award from the Department of Education to attend a workshop, 1997

• Special recognition by MOHONA Cultural group of Atlanta, 1996

• Kent State University Fellowship (1989)

• Waldo-Semon Graduate Research Award by KSU and B.F. Goodrich Company (1988)

• An award from the American Chemical Society (1988)

• Dissertation award (1988) at Kent State University

• Teaching Fellowship (1985-89) in the Department of Chemistry, Kent State University, Kent, Ohio.

• University Merit Scholarship (1975-80) for outstanding student in Jahangirnagar University

• Bangladesh Educational Board Scholarship (1978-80) for outstanding student in Jahangirnagar University

SOCIETY MEMBERSHIP

• American Chemical Society (ACS)

• Member of Organic Division

• Member, Tennessee Academy of Science

• Member, American Association for the Advancement of Science

PUBLICATIONS AND PRESENTED PAPERS

1] Synthesis and Characterization of New Schiff bases formed by Condensation of 2,9-Phenathroline-1,10-dialdehyde with Sulfur-containing Amines; Md. Arifuzzaman, Mohammad R. Karim, Tasneem A. Siddiquee, Aminul H. Mirza, Mohamad A. Ali, International Journal of Organic Chemistry, 2013, 3(1), 81-86

2] Template synthesis and X-ray structural characterization of nickel(II) and zinc(II) complexes of tetradentate SNNS ligands formed by condensation of phthalaldehyde with S-methyldithiocarbazate and 4N-methyl-3-thiosemicarbazide Mohammad Akbar Ali, Aminul Huq Mirza, Chan Chin Mei, Paul V. Bernhardt, Mohammad Rezaul Karim. Polyhedron, 2013, 49, 277-283.

3] Self-assembling dicopper(II) complexes of di-2-pyridyl ketone Schiff base ligands derived from alkyldithiocarbazates; Mohammad Akbar Ali, Aminul H. Mirzaa , Ray J. Butcherb, Paul V. Bernhardtc, Mohammad Rezaul Karimd; Polyhedron, 2011, 30(9), 1478-1485

4] “2,9-Bis(1,3-benzothiazol-2-yl)-1,10-phenanthroline dichloromethane disolvate” Jesmin Akther, Sergey Lindeman and Mohammad R. Karim; Acta Cryst 2008, E64, 01836

5] "N-Oxo radicals in the oxidation of lignin model compounds" Dr. Mohammad R. Karim, Department of Chemistry, Presented at the NASA SHARP Program, June 20, 2001.

6] "Hemicholinium - 3 Mustard Reveals Two Populations of Choline Cotransporters with Different Properties." M.T.Ivy, R.F.Newkirk, M.R. Karim, C.M.P.Mtshali and J.G.Townsel, Neuroscience, 2001, 102(4), 969-978.

7] "N-Oxo radicals in the oxidation of phenolic legnin compounds" Mustakim, Shiekh and Mohammad R. Karim, Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 20-21, 2000.

8] “Hemicholinium - 3 Mustard Derivative on Choline Cotransport: II. The Revelation of a Population of Silent Cotransporters; Michael T. Ivy, Robert F. Newkirk, Mohammad R. Karim, Charlie M.P. Mshatli and James G. Townsel; Neuroscience, 2000, Accepted.

9] "Revelation of Silent Choline Cotransporters" M.D. Kemp, R.F. Newkirk, M.T. Ivy, M.R. Karim and J.G. Townsel; Society for Neuroscience Conference, Los Angeles, California, , Nov 7-12, 1998.

10] "Hemicholinium Mustard Reveals a Constitutive Cycling Choline Cotransporter" R.F. Newkirk, M.T. Ivy, M.R. Karim, and J.G. Townsel; Society for Neuroscience Conference, Los Angeles, California, , Nov 7-12, 1998.

11] "A Hemicholinium-3 Mustard Reveals Two Populations of Choline Cotransporters with Different Properties” Michael T. Ivy, Mohammad R. Karim, Robert F. Newkirk, Byron D. Ford and James G. Townsel; Neuroscience Abstracts, 1998, Vol 23(2), p1239.

12] "Preparation and Nucleic-Acid Binding of Ellipticine Derivatives." Kennedy, G. D., Krishnan, G., Karim, M., and Harden, D. (1997). Heterocyclic Communications, 2, 125-128.

13] "Pulping Catalyst From Lignin (5). Nitrogen Dioxide Oxidation of Lignin Models to Benzoquinones", Dimmel, D. R.; Karim, M.R.; Savidakis, M.C; Bozell, J.J.; J. Wood Chem. Technol., 1996, 16, 169.

14] “Quantitative Structure-Activity Relationship Study of Taxol Analogues.” Mohammad R. Karim, 1st Biomedical Sciences And Engineering Symposium ’97, Nashville, Tennessee, August 6, 1997.

15] “Synthesis of highly functionalized allyl halides as useful synthetic intermediates.” Mohammad R. Karim and Kimberly Herron, Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 24-25, 1997.

16] "Synthesis of substituted indole and carbazole derivatives via intramolecular ene reaction" Mohammad R. Karim and Xiaoming Shan*, Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 24-25, 1997

17] "Approaches to the synthesis of AB ring of Taxol" Mohammad R. Karim and Seong Cho*, Department of Chemistry, College of Arts and Sciences University-Wide Research Day, March 24-25, 1997.

18] Kennedy, G. D., Krishnan, G., Karim, M., and Harden, D. (1996). Preparation and Nucleic-Acid Binding of Ellipticine Derivatives. Heterocyclic Communications, 2, 125-128.

19] “Effects of Electron Donating Groups on the Ene Donor in Intramolecular Ene Reaction”, M.R. Karim, Leon Smith, at 211th National Meeting of the American Chemical Society, March 24-28, 1996, in New Orleans, Louisiana (ORGN. 42)

20] “Synthesis and Ene Reaction of Model Compounds Containing Electron Donating Groups on the Ene Donor”. Dr. Mohammad R. Karim and Leon M. Smith* and , Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 25-26, 1996

21] “Synthesis and Ene Reaction of Benzenoid Model Compounds Containing Electron Donating Groups on the Ene Donor”. Mohammad R. Karim and Jidong Li*, Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 25-26, 1996

22] “Synthesis of Indole Derivatives Via Intramolecular Ene Reaction”. Mohammad R. Karim and Xiaoming Shan*, Department of Chemistry, College of Arts and Sciences. University-Wide Research Day, March 25-26, 1996

23] "Effects of Electron donating Groups on the ENE donor in Type III Intramolecular ENE Reaction" M.R. Karim, Leon Smith and Jidong Li, Tenn. Acad. Sc., 70:98, 1995.

24] "Effect of electron donating groups on the ene donor in type III intramolecular ene reaction", Seals, N; Whiteside, J.; Karim, M.R.* at 20th NIGMS Annual Conference, Nov 3-6,1993, in Atlanta, Georgia. Abstract No. 493.

25] "Synthesis of a New Class of Heterocyclic Compounds as Anti-Aids Drugs" , Kennedy, G.D.; Karim, M.R. Conference at Pensacola, 1992.

26] "Degradation of Dibenzodioxin during Chlorine Dioxide Bleaching of Kraft Pulp", Alison K. Daube, Mohammad R. Karim, Donald R. Karim, Thomas J. McDonough, Sujit Banerjee; Environ. Sci. Technol. 1992, 22, 1324

27] “Novel synthesis of macrocyclic keto lactones, and their utility in the construction of medium-sized carbocyclic rings via transannular aldol condensation reactions.” Karim, Mohammad Rezaul. Diss. Abstr. Int. B 1990, 51(1), 212.

28] "A new and Efficient Approach to Macrocyclic Ketolactones", Karim, M.R.; Sampson, P.* J. Org. Chem., 1990, 55, 598.

29] "An Improved Ozonolytic Approach to 6-Oxoheptanal", Karim, M.R.; Sampson, P.* Org. Prep. Proc. Intl. 1990, 22, 27.

30] "Transannular Aldol Condensation Within Macrocyclic Ketolactones: A novel Approach to 8-membered Carbocyclic Rings", Karim, M.R.; Sampson, P.*, Tetrahedron Lett. 1988, 29, 6897.

31] "Structure of Tinosporide- A Furanoid Diterpene from Tinospora cordifolia Myers", Ahmad, M.; Kazi, A.B.; Karim, M.R.; J. Bang. Acad. Sci. 1978, 2, 25.

32] "Use of Transannular Aldol Condensation Reaction within Macrocyclic Ketolactones for the Construction of Medium-Sized Carbocyclic Rings", Karim, M.R.; Chai, K.B.; Sampson, P.* manuscript in preparation.

33] Use of Ti(III) Ion Peroxide-Induced Radical Addition Reaction in the Synthesis of Long-Chain Polyfunctionalized Carboxyxlic acids or Esters", Karim, M.R.; Fillippini, B. B., Sampson, P.* manuscript in preparation.

34] "Transannular Reactions Within Macrocyclic Lactones: A Novel Approach to 8-Membered Carbocyclic Rings", Mohammad R. Karim, Paul Sampson*, at 20th Central regional Meeting of the American Chemical Society, June, June 1-3, 1988, in Morgantown, West Virginia (abstr. no. 116)

35] "Transannular Reactions Within Macrocyclic Lactones: A Novel Approach to 8-Membered Carbocyclic Rings", Mohammad R. Karim, Paul Sampson*, at 196th National Meeting of the American Chemical Society, Sept. 25-30, 1988, in Los Angeles, California (ORGN. 156)

36] "An Efficient Approach to Macrocyclic Ketolactones", Mohammad R. Karim, Paul Sampson*, at 21st Central Regional Meeting of American Chemical Society, May 31st-June 2nd, 1989,Cleveland, Ohio.

37] "Use of Tritium-Labeled Dibenzo-p-Dioxin in Bleaching Kraft Pulp", Alison K. Daube, Mohammad R. Karim, Donald R. Dimmel, Thomas J. McDonough and Sujit Banerjee, at 201st National Meeting of the American Chemical Society, April 14-19, 1991, in Atlanta, Georgia (CELL 0030)

Book Review:

• Fundamentals of Chemistry, Chapters 5 and 9, 3rd edition by David Goldberg, McGraw-Hill Publisher, January 2001.

• Modern Organic Synthesis: An Introduction by Michael Nantz and George Zweifel W.H. Freeman and Company, Publishers. May, 2005

GRANTS AND CONTRACTS:

• Principal Investigator: Strengthening Chemistry Graduate Program. $1.9M for 5 years. Funded by Department of Education (2009-2014)

• Principal Investigator: Strengthening Chemistry Graduate Program. $1.62M for 5 years. Funded by Department of Education (2004-2009)

• Principal Investigator: “Developing Technical Capabilities of Tennessee State University in the areas of Business, Engineering and Science”; Sponsor: BWXT-Y-12 at Oak Ridge. Total Cost: $30,000.00. Period July 2001- November 2001, Funded.

• Principal Investigator: “Synthesis of anticancer and anti-AIDS agents via Intramolecular Type III ene Reaction”; Sponsor: National Institute of Health- Minority Biomedical Research Support. Total Direct Cost: $135,684.00. Period: September 1994- March 1998. Funded.

• Program Director: “Chemistry and Physics Enrichment Program for High School Teachers (Grades 9-12), Submitted to State of Tennessee, Higher Education Commission, Total Amount: $29,764. Not Funded.

• Principal Investigator: “Synthesis of analogs of anticancer agent - Taxol” Sponsor: Research Corporation. Total amount: $37,200, Not Funded.

• Principal Investigator: “Minority Biomedical Research Support Program”, Sponsor: National Institute of Health. Total amount requested: $65,000, Not Funded.

• Principal Investigator: “Development of a unique synthetic strategy to the synthesis of anticancer agent -Taxol” Sponsor: National Science Foundation. Total amount requested: $325,044, Not Funded.

• Principal Investigator: “Synthesis of Natural product analogs as potential anticancer and anti-AIDS agents.” Sponsor: National Institute of Health (NIH). Total amount requested: $382,293.00 over 4 years. Status: Not Funded.

• Principal Investigator: “Ene Reaction in the Synthesis of Alkaloids." Sponsor: National Institute of Health (NIH). Total amount requested: $382,293.00 over 4 years. Status: Not Funded.

• Collaborator: "Molecular Aspects of Cholinergic Cotransporter Regulation." Status: Funded.

UNIVERSITY AND PUBLIC SRVICE:

• Member, Academic Affairs Budget Advisory Committee (2008-Present)

• Member, Graduate Council (July 2009 - Present)

• Chair, Graduate curriculum Committee (Sept. 98- Dec 99)

• Graduate Coordinator (June 98- Dec 99)

• Chair, University safety Committee (1997-Present)

• Member, Graduate Council (Aug 97-Dec 1999)

• Member, Premed Advisory Committee (Aug. 97- Present)

• Faculty Advisor, Chemistry Club, Department of Chemistry, TSU(1994-97)

• Member, Undergraduate Curriculum Committee (1994-1995)

• Chair, Exhibits and Display Committee, Science Exposition March 18-22, 97; TSU

• Served as a Judge at Martin Luther King Jr. High School Science fair (1997)

• Served as a Judge at Tennessee State University Science fair, March 18-22, 1997.

• Member of Organizing Committee on 1st Biomedical Sciences and Engineering Symposium ’97.

• Made a presentation at Bellevue Middle School as part of our Departmental Recruiting Effort on Nov 28, 2000.

• Member of the Chemistry Department Safety Committee, 2000-01

• Member of the Chemistry Department Graduate Committee, 2000-01

• Served as a sequester juror at the Metro Court House, August 13-17, 2001

• Member of the Chemistry Department Undergraduate Committee, 2001-02

• Member of the Chemistry Department Graduate Committee, 2001-02






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