Synthesis of Schiff Bases from 2,9-dimethyl-1,10-phenanthroline dialdehyde and sulfur-containing amines
Zinia’s Research Focus:
Recently nitrogen and sulfur-containing organic chelating agents such as the Schiff bases derived from 2,9-dimethyl-1,10-phenanthroline dialdehyde and sulfur-containing amines and their metal complexes have received considerable attention because of their important roles in synthetic and medicinal chemistry. By properly designing this type of compounds and studying their structure-activity relationships, potentially useful antibacterial, antifungal and anticancer agents can also be synthesized . 2,9-Dimethyl-1,10-phenanthroline and its derivatives from which 2,9-dimethyl-1,10- phenanthroline dialdehydes are prepared, are themselves important ligands for complexation with many metal ions . This property has made them important in different areas like self-assembly and catalysis. It has also played a significant role in both analytical and preparative coordination chemistry as well as in the preparation of many mixed-ligand complexes .
Although a large number of Schiff bases containing ‘hard’ nitrogen and ‘soft’ sulfur donor atoms have been synthesized using S-alkyl/aryl dithiocarbazates and heterocyclic aldehydes and ketones, which are able to form stable complexes with a variety of metal ions , less work has been reported on Schiff bases formed by condensation of 1,10-phenanthroline dialdehydes with sufur- containing amines such as S-alkyl/aryl dithioicarbazates, thiosemicarbazide and aminobenzenethiol.
In view of the importance of Schiff bases derived from 1,10-phenanthroline dialdehyde and sulfur-containing amines in coordination chemistry and biology, we report here the synthesis and characterization of eight new Schiff bases formed by condensation of 5-nitro-1,10-phenanthroline- 2,9-dialdehyde and 5-bromo-1,10-phenanthroline -2,9-dialdehyde with different types of sulfur-containing amines.
“Synthesis of 5-Substituted 2, 9-Dimethyl-1,10-Phenanthroline Dialdehydes and Their Schiff bases with Sulfur-containing Amines”. Zinia Jaman *, Mohammad R. Karim**, Tasneem A. Siddiquee*, Aminul H. Mirza†, Mohamad A. Ali†. International Journal of Organic Chemistry, 2013, Vol 3, No. 3, Accepted
 Kumar, S., Dhar, D.N., Saxena, P.N., “Applications of Metal Complexes of Schiff Bases – A Review”. Journal of Scientific and Industrial research, 2009, 68, 181