Dr. Yousef Beni

Assistant Professor, Organic Chemistry

Beni

Assistant Professor-Organic and Medicinal Chemistry

Department of Chemistry

Contact Information:

Office: Boswell Complex Room 213

Phone: 615-963-5333

Fax: 615-963-5326

Email: ybeni@tnstate.edu

EDUCATION:

Postdoctoral Fellow    University of Rhode Island, Kingston, RI (Medicinal Chemistry; 2004-2008)

Ph.D.   Sharif University of Technology and Justus-Liebig University, Giessen, Germany (Org Chem; 1997-2002)

M.Sc.  Sharif University of Technology, Tehran, Iran (Organic Chemistry; 1995-1997)

B.Sc.   Tabriz University, Tabriz, Iran (Applied Chemistry; 1991-1995)

HONORS AND AWARDS:

  • Academic achievement award for individual contribution to the field in research/scholarly activity, Columbus State University, Columbus, GA., 2010.
  • Sharif University of Technology outstanding graduate of the year award for the best PhD graduate, Sharif University of Technology, Tehran, Iran 2002.
  • Visiting scholar’s award, awarded by German research society "Deutsche Forschrung Gemeinschaft, DFG" for conducting research at the Justus-Liebig University, Giessen, Germany, 2000.
  • Young scientist travel award, sponsored by Ministry of Science, Research and Technology for travel to Justus-Liebig University, Giessen, Germany, 2000.
    • Managing editor, Sharif Journal of Chemistry, Published by department of chemistry, Sharif University of Technology, 1998-2000.
    • Research scholarship, Ministry of Science, Research and Technology for completing PhD program at Sharif University of Technology and Justus-Liebig University, Giessen, Germany, 1997.

TEACHING:

  • General Chemistry
  • Organic Chemistry
  • Spectroscopic Identification of Organic Compounds      (Graduate)
  • Polymer Chemistry (Graduate)
  • Survey of Chemistry

RESEARCH INTERESTS:

  • Anticancer drug discovery and development by chemical modification
  • Synthesis and application of phosphorylated nucleotides as anti-HIV agents
  • Synthesis and evaluation of modified oligodeoxynucleotides

RECENT PUBLICATIONS (Last 5 Years):

  1. Dash,C., Beni, Y., Hanley, M. J., Pandhare, J., Gotte, M., Le Grice, S. F. J., Parang, K., Inhibition of multi-drug resistant HIV-1 reverse transcriptase by nucleoside β-triphosphates, Bioorg. Med. Chem. Lett., 2011, 21, 3519–3522.
  2. Gupta, A., Mandal, D., Beni, Y., Parang, K., Bothun, G., Hydrophobicity Drives the Cellular Uptake of Short Cationic Peptide Ligands, Eur. Biophys. J., 2011, 40, 727–736.
  3. Beni, Y., Tiwari, R., Swepsonc C., Pandharec, J., Dash, C., Donceld, G. F., Parang, K., Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3′-fluoro-3′-deoxythymidine and 3′-azido-3′-deoxythymidine, Tet. Letters, 2011 , 52, 802-805.
  4. Beni, Y., Dash,C., Hanley, M. J., Le Grice, S. F. J., Parang, K., Solid-Phase Synthesis of 5'-O-β,γ-Methylenetriphosphate Derivatives of Nucleosides and Evaluation of Their Inhibitory Activity Against HIV-1 Reverse Transcriptase, Tet. Letters,.2010 , 51, 3010–3013.
  5. Beni, Y., Dash,C., Hanley, M. J., Le Grice, S. F. J., Agarwal., H. K., Parang, K., Synthesis and of Nucleoside 5'-O-α,β-Methylene-β-Triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase, Org. Biomol. Chem.,.2010 , 8, 1271–1274.
  6. Beni, Y., Tiwari, R., Sun, G., Parang, K.; Synthesis of nucleoside mono-, di-, and triphosphoramidates from solid-phase cycloSaligenyl phosphitylating reagents. Org. Lett., 2009, 11, 2157-2160.
  7. Ye,G., Schuler, A., Beni,Y., Morgan, J. R., Faruqui,A., Huang, K., Sun,G., Zebala, J. A., Parang, K. Synthesis and evaluation of peptides containing iminodiacetate groups as binding ligands of the Src SH2 domain. Bioorg. Chem. 2009, 37, 133-142.
  8. Beni, Y.; Parang, K.; Solid-supported reagents for synthesis of nucleoside monothiophosphates, dithiodiphosphates, and trithiotriphosphates, Current Protocols in Nucleic Acid Chemistry,2009 , Unit 13.9, Supplement 33, Wiley.
  9. Beni, Y.; Parang, K.; Solid-supported diphosphitylating and tr iphosphitylating reagents for nucleoside modification, Current Protocols in Nucleic Acid Chemistry,2008, Unit 13.8, Supplement 33, Wiley.
  10. Beni, Y.; Parang, K.; Synthesis and evaluation of oligodeoxynucleotides containing internucleotide diphosphodiester linkages, Angew . Chem. Int. Ed., 2007, 46, 4739-4743.
  11. Beni, Y.; Parang, K., Solid-phase synthesis of symmetrical 5′,5′-dinucleoside mono-, di-, tri-, and tetraphosphodiesters, Org. lett., 2007, 9, 4483-4486.
  12. Bhandari, R.; Saiardi, A.; Beni, Y.; Snowman, A. M.; Resnick, A. C.; Kristiansen, T. Z.; Molina, H.; Pandey A.; Werner, J. K.; Juluri, K. R.; Xu, Y.; Prestwich, G. D.; Parang, K.; Snyder S. H., Protein pyrophosphorylation by inisitol pyrophosphates is a posttranslational event, Proc. Nat. Acad. Sci. U.S.A. , 2007, 104, 15305-15310.
  13. Beni, Y., Hanley, M. J., White, M., Ayrapetov, M., Lin, X., Sun, G., Parang, K., Metal-binding properties of a dicysteine-containing motif in protein tyrosine kinases, ChemBioChem, 2007, 8, 1592-1605.

PUBLISHED MEETING ABSTRACTS (Last 5 Years):

  1. Beni, Y., Love, J. M., From food antioxidants to gold nanoparticles, determination of antioxidants in natural and processed food by gold, 243rd ACS National Meeting & Exposition, San Diego, CA, United States, March 25−29, 2012, Abstract # 228 .
  2. Beni, Y. Pippas, G., Love, J. M., Evaluation of cancer preventer foods/spices by gold nanoparticles, Georgia Academy of Science Annual Meeting, Kennesaw, Georgia., United States, March 23 – 24, 2012, Abstract # 132 .
  3. Beni, Y., Williams T., Seeram, N., Parang K., Triphenylmethanol derivatives: synthesis and application as acid-base indicators for acid-base titrations, 63rd Southeastern Regional Meeting of the ACS (SERMACS). Richmond, VA, United States, October 26-29, 2011, Abstract # 239.
  4. Beni, Y., Dash, C., Hanley, M. J., Le Grice, S. F. J., Agarwal, H. K., Parang, K., Structure-activity relationship studies of modified nucleoside β-triphosphates for polymerase and RNase H of HIV-1 reverse transcriptase, 43rd IUPAC World Chemistry Congress, San Juan, PR, United States, July 30-August 7, 2011, Abstract # 592 .
  5. Beni, Y., Shirazi, A. N., Parang, K., Metal-binding properties of cyclic peptides, 43rd IUPAC World Chemistry Congress, San Juan, PR, United States, July 30-August 7, 2011, Abstract # 594 .
  6. Beni, Y., Dash, C., Hanley, M. J., Pandhare, J., Gotte, M., Le Grice, S. F. J., Parang, K., Synthesis and evaluation of nucleoside β-triphosphates as multi-drug resistant HIV-1 RT inhibitors, 43rd IUPAC World Chemistry Congress, San Juan, PR, United States, July 30-August 7, 2011, Abstract # 597 .
  7. Beni, Y., Dabke, R., Wendell G., Radical electropolymerization of pyrrole: Improvement of conductivity in polypyrrole homopolymers, 43rd IUPAC World Chemistry Congress, San Juan, PR, United States, July 30-August 7, 2011, Abstract # 924 .
  8. Beni, Y., Love, J. M., Rugutt, J., Introducing Nanotechnology to Undergraduate Chemistry Curriculum, 42nd Middle Atlantic Regional Meeting of the American Chemical Society, College Park, MD, United States, May 21-24, 2011, Abstract # MARM-134 .
  9. Beni, Y., Gina D. N. D., Improvement of conductivity in polythiophenes, Joint 66th Southwest and 62nd Southeast Regional Meeting of the American Chemical Society, New Orleans, LA, United States, December 1-4, 2010, Abstract # SESW-351 .
  10. Beni, Y., Wendell C., Synthesis of modified conductivie polypyrroles, Joint 66th Southwest and 62nd Southeast Regional Meeting of the American Chemical Society, New Orleans, LA, United States, December 1-4, 2010, Abstract # SESW-323 .
  11. Beni, Y., Tiwari, R., Parang K., Synthesis of bis(cycloSaligenyl) pronucleotides containing two nucleosides from bis(methoxymethyl)benzene-1,4-diol, 240th ACS National Meeting & Exposition, Boston, MA, United States, August 22-26, 2010, Abstract # ORGN 1075 .
  12. Beni, Y., Carrol, B., Parang K., Synthesis of lipophilic dodecyl bis(cycloSaligenyl) nucleoside monophosphate triesters, 240th ACS National Meeting & Exposition, Boston, MA, United States, August 22-26, 2010, Abstract # ORGN 1019.
  13. Beni, Y., Parang K., Synthesis of branched lipophilic thymidine β-triphosphate triester conjugates of anti-HIV nucleosides, 240th ACS National Meeting & Exposition, Boston, MA, United States, August 22-26, 2010, Abstract # ORGN 1020.
  14. Beni, Y., New indicators for the acid-base volumetric titrations, Georgia Academy of Science Annual Meeting, Columbus, GA, United States, March 26 – 27, 2010, Abstract # CHEM 002.
  15. Beni, Y., Grainger, W., Improvement of conductivity in polypyrrole homopolymers, Georgia Academy of Science Annual Meeting, Columbus, GA, United States, March 26 – 27, 2010, Abstract # CHEM 001.
  16. Beni, Y., Tiwari, R., Doncel G. F., Parang, K., Bis(cycloSaligenyl) derivatives of nucleosides: Synthesis and anti-HIV activities, 238th ACS National Meeting & Exposition, Washington, DC, United States, Aug. 16-20, 2009, Abstract # MEDI 114.
  17. Beni, Y.; Tiwari, R., Parang, K., Tris(2-(hydroxymethyl)phenol) derivatives: Synthesis and application as acid/base indicators, 238th ACS National Meeting & Exposition, Washington, DC, United States, Aug. 16-20, 2009, Abstract # ANYL 117.
  18. Beni, Y.; Tiwari, R., Parang, K., Using polymer-bound bi(cycloSaligenyl) phosphitylating reagents for the synthesis of nucleoside mono-, di-, and triphosphates , 238th ACS National Meeting & Exposition, Washington, DC, United States, Aug. 16-20, 2009, Abstract # ORGN 524.
  19. Beni, Y.; Tiwari, R., Parang, K., Application of polymer-bound salicyl alcohol for the synthesis of nucleoside mono-, di-, and triphosphoramidates , 238th ACS National Meeting & Exposition, Washington, DC, United States, Aug. 16-20, 2009, Abstract # ORGN 424.
  20. Beni, Y., Parang, K., Solid-Phase Phosphitylating Reagents: Design and Application in the Synthesis of Phosphorylated Biomolecules, 61th Southeastern Regional Meeting of the ACS (SERMACS). San Juan, PR, United States, October 20-24, 2009, Abstract # BORG-473
  21. Beni, Y., Antisense ODNs Containing Diphosphodiester Internucleotide Linkages for Cancer Treatment, 8th Annual University-Wide Faculty Research Forum Series, Columbus, GA, United States, February 5, 2009, Forum #3, Abstract # 2.
  22. Beni, Y., Parang, K., Laboratory Teaching of Solid-Phase Reaction, 60th Southeastern Regional Meeting of the ACS (SERMACS). Nashville, TN, United States, November 12-15, 2008, Abstract # CHED-552.
  23. Beni, Y., Parang, K., Synthesis and evaluation of dendrimer modified oligodeoxynucleotides containing β-triphosphotriester internucleotide bridges, 236th ACS National Meeting & Exposition, Philadelphia, PA, United States, August 17-21, 2008, Abstract # ORGN-274.
  24. Beni, Y.; Tiwari, R., Parang, K., Application of polymer-bound salicyl alcohol for the synthesis of nucleoside 5'-O-monophosphates, 236th ACS National Meeting & Exposition, Philadelphia, PA, United States, August 17-21, 2008, Abstract # ORGN-660.
  25. Beni, Y.; Parang, K.,Circular dichroism, thermal denaturation, and nuclease stability studies of modified oligodeoxynucleotides containing mixed sequences of four nucleosides attached through diphosphodiester bridges, 234td ACS National Meeting & Exposition, Boston, MA, United States, August 19-23, 2007, Abstract # ORGN-151.
  26. Beni, Y., Bhandari, R., Snyder, S. H.; Parang, K.,Synthesis of pyrophosphopeptides and methylphosphopeptides, 234td ACS National Meeting & Exposition, Boston, MA, United States, August 19-23, 2007,Abstract # ORGN-903.
  27. Beni, Y., Hanley, M., Agarwal, H. K.; Parang, K.,Applications of polymer-bound phosphitylating reagents in the synthesis of organophosphorus compounds, 233rd ACS National Meeting & Exposition, Chicago, IL, United States, March 25-29, 2007, ,Abstract # ORGN-240.
  28. Beni, Y.; Parang, K., Solid-phase synthesis of symmetrical dinucleoside monophosphodiesters, diphosphodiesters, triphosphodiesters, and tetraphosphodiesters, 233rd ACS National Meeting & Exposition, Chicago, IL, United States, March 25-29, 2007, Abstract # ORGN-640.
  29. Beni, Y.; Parang, K.,Interactions of transition metals with cysteine-containing peptides, 233rd ACS National Meeting & Exposition, Chicago, IL, United States, March 25-29, 2007, Abstract # INOR-256.
  30. Beni, Y., Hanley, M., Agarwal,H. K.; Parang, K., Synthesis of nucleoside 5'-O-beta-triphosphates containing alpha-beta methylene bridge,233rd ACS National Meeting & Exposition, Chicago, IL, United States, March 25-29, 2007, Abstract # ORGN-641.
  31. Beni, Y.; Parang, K., Solid-phase synthesis of 5'-O-(alpha, beta-methylene)triphosphate and 5'-O-(beta, gamma-methylene)triphosphate derivatives of nucleosides, 233rd ACS National Meeting & Exposition, Chicago, IL, United States, March 25-29, 2007, Abstract # ORGN-639.

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