College of Arts and Sciences

Department of Biological Sciences

Fall 2008

Biology 5180-Cell Biology

3.0 Credit Hours

INSTRUCTOR: John T. Robinson, Jr., Ph.D.

OFFICE PHONE: (615) 963-5762

OFFICE LOCATION: 112-H McCord Hall

OFFICE HOURS: MW 9:00-10:30 am 11:30 am – 12:45 pm;

TR 11:00am-2:00 pm F: 9:00-10:00am

E-MAIL jrobinson@tnstate.edu

Lectures will be from 5:00 to 8:00 pm on Thursday. Lectures will take place in McCord Hall, Room 104.

TEXTBOOK: Molecular Cell Biology 6^th Edition , Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty Krieger, Matthew P. Scott, Anthony Bretscher, Hidde Ploegh and Paul Matsudaira W. H. W.H. Freeman & Co., 2008. Topic Comparision (5th and 6th editions of text)

Course Description: Biology 5180, Cell Biology: The structure and behavior of the cell and its components with special emphasis on cell division. Prerequisite: Permission of instructor. Required of all degree candidates. Three credit hours.

General Goals Objectives: The objectives of this course are to provide students with an in depth and up to date knowledge on a variety of topics in cell biology with special concentration on macromolecules and reactions studied by biochemists, cellular processes studied by biochemists and gene control pathways. Included in these discussions will be information on new discoveries from genome-based research and newly developed biotechnology.

Course Purpose/Rationale: To provide a basic understanding of cellular activities and cellular processes including cellular transport, cell energetics, cell motility, cell interactions and signal transduction, cell division, and regulation of gene expression.

Course Requirements: There will be assigned reading assignments from your textbook each week. Additionally, there will be approximately 5 – 10 assigned journal articles to read during the semester. Students are expected to complete reading assignments before coming to class. Assigned articles will be discussed in class. Other requirements include written assignments and in class participation.

Class Attendance: Punctual class attendance is required for all class sessions. Attendance records will be kept for every class meeting. Class absences will be recorded and reported to the Records Office in accordance with University policy.

Reference Materials: Assigned journal articles, class assignments, on-line resource and cell biology links may be accessed from either my Cell Biology website or Mytsu online course files.

METHOD OF EVALUATION: There will be three exams, including a final exam. There will also be an out of class written assignment. The final grade will be based upon grades exams, class participation, and written assignments. The final grade will be computed as follows:

Exams 55%

Class Participation 10%

Written Assignments 15%

Final Exam 20%

EXAMS: Exams are expected to be taken on the day and time that have been pre-assigned in the class schedule. Any change in this policy will be granted only in extenuating circumstances. Official written excused absences must accompany any request for re-scheduling of an exam.

DISHONESTY: Plagiarism, cheating, and other forms of academic dishonesty are not permitted. Students guilty of academic misconduct either directly and indirectly through participation or assistance, immediately become responsible to the instructor of the class. The instructor has the authority to assign an F in the course. Additionally, the student will face possible disciplinary sanctions for academic misconduct imposed by the University through regular institutional procedures. (If a student believes that he/she has been erroneously accused of misconduct, and if his/her final grade has been lowered as a result, the student may appeal through appropriate institutional procedures (See Student Handbook).

GRADING:

A student completing the course will be assigned a grade earned according to scale below:

Grade Score Range

A 90-100

B 80-89

C 70-79

D 60-69

F 0-59

COURSE SCHEDULE

Date Week Topic Reading Assignment/Chapter(s)

Part 1 Chemical and Molecular Foundations

08/28/08 1 Life and Cell Connection 1 Lecturech1

09/04/08 2 Life and Cell Connection

Chemical Foundations/Proteins 1,2 Lecturech2

09/11/08 3 Protein Structure/Function 3 Lecturech3

Molecular Genetic Mechanisms 4 Lectch4 PPTFigs Questions

09/18/08 4 Molecular Genetics Techniques 5 Lectch5 PPTFigs Questions

09/25/08 5 EXAM 1

Part 2: Cell Organization and Biochemistry

10/02/08 6 Biomembranes/Cell Membranes 10 Lect10 PPT Questionsch10

10/09/08 7 Membrane Transport/Nerves 11,23 Lectch11 PPT11 Lectch23 PPT23

Question-ch11&23

10/16/08 8 Cellular Energetics 12 Lectch12 PPTch12 Questions12

10/23/08 9

Part 3: Genetics and Molecular Biology

10/30/08 10 Genes, Genomics and Chromosomes 6 Lectch6

11/06/08 11 Transcriptional and Post Transcriptional

Control 7,21, 22 Lectch7

Part 4: Cell Signaling, Cell Cycle-Growth Control

11/13/08 12

11/20/08 14 Cell Cycle 20 Lectch20

EXAM- EXAM 2

11/27/08 13 Thanksgiving Day Holiday No Class

Part 5: The Cytoskeleton, Cells into Tissues, Developmental Molecular Cell Biology

12/04/08 15 The Cytoskeleton 17,18, Lectch17 Lectch18

Integrating Cells into Tissues 19 Lectch19

Developmental Molecular Cell Biology Lectch22

12/11/08 FINAL EXAM

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*Additional Resources: Molecular Cell Biology-6edition (Lodish) website: http://www.whfreeman.com/lodish6e

Exam Dates: 9/25/08, 10/23/08, 11/13/08 and final in December (Tentatively, December 11, 2008; 5-7 pm)

*Disclaimer: The professor reserves the right to make changes in this document as deemed

necessary.

**Make sure all cell phones and digital alarming devices are turned off while in class.